Refining the definition of mandibular osteoradionecrosis in clinical trials: The cancer research UK HOPON trial (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis)

Mandibular osteoradionecrosis (ORN) is a common complication of radiotherapy for head and neck malignancy whereby the bone undergoes necrosis, becoming exposed. This is usually symptomatic and may cause intra- or extra-oral fistulae, infection, pain and eventually pathological fracture [1]. The consequences of these complications include malnutrition, opiate dependency, haemorrhage, sepsis, with progressive disfigurement and deterioration in quality of life. The incidence of head and neck cancer, survival and proportion receiving radiotherapy are all increasing, in part, due to Human Papillomavirus related cases [2,3].

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