• Medical claims were used to evaluate comorbidities in 9,312 narcolepsy subjects.• Comparisons were made using claims from a group of 46,559 matched controls.• All comorbidities studied were significantly more prevalent in narcolepsy patients.• The only exceptions were perinatal and pregnancy/childbirth-related comorbidities.• Anxiety and depression were the comorbidities with the greatest excess prevalence.
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