Prediction of outcome by lymph node ratio in patients with parotid gland cancer

Abstract

Objective

Lymph node ratio (LNR) has been shown to be an independent predictor of recurrence risk and survival in different entities of carcinoma.

Methods

In this retrospective chart review 128 patients with parotid gland cancer subsequently treated by primary surgery were included. 64% (n=82) of these patients were additionally treated with adjuvant radiotherapy. Five-year overall survival rates were determined by subgroups based on LNR value.

Results

LNR was found to be significantly associated with overall survival rate (p<0.001). Using univariate analyses, pathological TNM-stage, UICC-stage grouping and extracapsular spread were found to be significant predictors of overall survival (p<0.001). However, with a multivariate analyses LNR remained the only independent predictor of overall survival (p=0.043).

Conclusions

After surgery for parotid gland cancer, evaluation of the neck using LNR was found to reliably stratify the overall survival rate.

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