Intensity modulated radiotherapy (IMRT) has emerged as the favored radiation modality for the definitive and post operative treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) [1,2]. Numerous prospective studies have demonstrated comparable tumor control rates with lower incidence of acute and late toxicities when comparing IMRT to conventional radiotherapeutic techniques [3–5]. Despite these advances, treatment related morbidity remains significant and strategies to mitigate the late effects of radiotherapy are still needed.
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