Urinary proteins as potential biomarkers for adult patients with obstructive sleep apnea

Introduction: Obstructive sleep apnea (OSA) is an emerging major public health problem in both developing and developed countries and is associated with several adverse health consequences. In India, it was found to have a prevalence of 19- 13% in males and 5-7% in adult females. In-hospital polysomnography is an onerous and expensive diagnostic modality for the patient; therefore, there is a need for a disease related biomarker for screening patients with OSA. Repetitive hypoxia and re-oxygenation during sleep in OSA patients result in endothelial dysfunction in patients with OSA and this may cause some intracellular proteins to leak out in the blood and urine of these patients.

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