The conformation of BSA adsorbed to the surface of single all-dielectric nanoparticles following light-induced heating

Interaction between nanoparticles and biomolecules leads to the formation of biocompatible or bioadverse complexes. Despite the rapid development of nanotechnologies for biology and medicine, relatively little is known about the structure of such complexes. Here, we report on the changes in conformation of a blood protein (bovine serum albumin) adsorbed on surface of single all-dielectric nanoparticles (silicon and germanium) following light-induced heating to 640 K. This protein is considerably more resistant to heat when adsorbed on the nanoparticle than when in solution or the solid state. Intriguingly, with germanium nanoparticles this heat resistance is more pronounced than with silicon. These observations will facilitate biocompatible usage of all-dielectric nanoparticles.

from ORL via alkiviadis.1961 on Inoreader http://ift.tt/2BXz1zB