Πέμπτη 1 Φεβρουαρίου 2018

Tasimelteon improves sleep quality and behavior in individuals with Smith-Magenis syndrome (SMS) in an open-label study

Introduction: Individuals diagnosed with Smith-Magenis Syndrome (SMS), a rare genetic disorder due to a deletion on chromosome 17, typically exhibit self-injurious and aggressive behaviors and disrupted nighttime sleep (i.e., difficulties falling asleep or frequent, prolonged nighttime awakenings). The associated nighttime sleep disturbances may be related to the observed inappropriate timing of the endogenous melatonin secretion during the daytime in this population.

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