The circadian rhythms of oxidative stress markers and melatonin metabolite in patients with autistic spectrum disorders

Introduction: Patients with autistic spectrum disorder (ASD) often have sleep problems, such as having difficulties in falling asleep, awakening frequently during night and waking up early in the morning. The relation between melatonin and sleep problems in ASD patients has been reported. Oxidative stress originates from an imbalance between the production of reactive oxygen species and reactive nitrogen species, and the antioxidant capacities of cells and organs. The relationship between oxidative stress and neurodegenerative disease has been reported.

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