Severity of REM sleep muscle atonia loss in idiopathic REM sleep behaviour disorder correlates with the degree of abnormalities in the vestibular evoked myogenic potentials

Introduction: The aim of this research is to correlate the severity of REM atonia loss in idiopathic REM sleep behavior disorder (iRBD) with vestibular-evoked myogenic potentials (VEMP) scores, which provide an indirect measure of severity of VEMP alterations. Brainstem dysfunction in established Parkinson's Disease (PD) has been associated with a consistent VEMP impairment, with alterations reported even in the early stages of the disease1,2. A misfunction of complex neurotransmitter connections within the brainstem probably accounts for the pathophysiology of iRBD, which is thought to predate synucleinopathies, such as PD, by many years3.

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