Management of facial pyoderma gangrenosum using platelet-rich fibrin: a technical report

Publication date: Available online 31 January 2018
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Leonzio Fortunato, Selene Barone, Francesco Bennardo, Amerigo Giudice
This report describes a case of local pyoderma gangrenosum that was treated with short-term immunosuppressive therapy and the topical application of platelet-rich fibrin (PRF).Medical treatment included an oral corticosteroid therapy and a topical treatment with PRF in solid and liquid form. The previously mentioned therapy initially led to the reduction of the ulcer's size and an improvement of the symptoms, until the ulcer was completely healed after a few weeks. A relapse was treated only with the application of PRF to the affected tissue with an excellent recovery. The efficacy of PRF as a guide for wound healing is due to the continuous release of growth factors involved in tissue repair mechanisms. PRF has proved to be suitable for the management of facial pyoderma gangrenosum while allowing a reduction of systemic corticosteroids therapy. The ease of preparation, low cost, and outpatient use make PRF an optimal scaffold for tissue healing processes. 



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