Telltale tumor infiltrating lymphocytes (TIL) in oral, head & neck cancer

Head and Neck Squamous Cell Carcinomas (HNSCC) are comprised of a number of epithelial malignancies arising in the mucosa of the upper aerodigestive tract. Immune cell infiltration is a prominent pathologic feature of HNSCC. First, due to the close proximity of these tumors to lymphoid tissue in the Waldeyer's ring, dense infiltrates of immune cells are frequently an integral component of the lesion. In addition, some types of HNSCC are driven by viral infection, such as human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma, and Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma.

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