Prognostic role of negative plasma EBV DNA level in patients with NPC

I read with great interest the study published by Lu et al. [1]. Authors very nicely evaluated the prognostic effect of combining tumor volume with pre-treatment plasma Epstein-Barr virus DNA (EBV DNA) in patients treated with intensity-modulated radiotherapy in nasopharyngeal carcinoma (NPC) patients. Briefly, they analyzed 3 different threshold values for probable prognostic role of gross tumor volume of nasopharynx and plasma EBV DNA level. They found that 20cc and 6800 copies/mL are threshold values for a statistically significant difference.

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