Oncologic outcomes and patient-reported quality of life in patients with oropharyngeal squamous cell carcinoma treated with definitive transoral robotic surgery versus definitive chemoradiation

Treatment regimens for oropharyngeal squamous cell carcinoma (OPSCC) have transformed over recent decades due to advancements in all treatment modalities [1–3]. Definitive chemoradiation is now the treatment of choice in most institutions, although this regimen is associated with severe acute and late toxicities which are further exacerbated by chemotherapy [4]. Common toxicities include mucositis, dysgeusia, and xerostomia resulting in increased risk of mucosal trauma and oral infections, all of which limit treatment success and detract from quality of life [5].

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