Chitinase-3-like protein-1 (YKL-40) as a marker of endothelial dysfunction in obstructive sleep apnea

• Hypertension is one of the most common complications of obstructive sleep apnea (OSA). However, approximately, one-third of patients with OSA do not have hypertension despite similar exposure to apneas, hypopneas, and intermittent hypoxia. The mechanism (s) of susceptibility or resilience to the development of hypertension in this population is unknown.• Several studies demonstrate, that elevated serum Chitinase-3-like protein-1 (also known as YKL-40) levels are independently associated with the presence and extent of coronary artery disease and with all-cause as well as cardiovascular mortality.

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