Burst firing of single neurons in the human medial temporal lobe changes before epileptic seizures

Epilepsy is not a disease in and of itself, but a chronic condition of the brain characterized by paroxysmal and recurrent epileptic events that occur as a result of chronic structural and/or functional changes. A number of studies have investigated seizure initiation at a neuronal population level using EEG or local field potential (LFP) recordings both in humans and animal models of epilepsy (Szabo et al. 2015). However, it is not possible to extrapolate meaningfully from this population level to the behavior of its cellular elements, even though they underlie this activity.

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