Update on local allergic rhinitis

Publication date: August 2016
Source:International Journal of Pediatric Otorhinolaryngology, Volume 87
Author(s): Niyazi Altıntoprak, Murat Kar, Nuray Bayar Muluk, Tugba Oktemer, Kagan Ipci, Leman Birdane, Mitat Aricigil, Mehmet Senturk, Sameer Ali Bafaqeeh, Cemal Cingi
We here provide an update on the literature regarding local allergic rhinitis (LAR). In reviewing LAR, we have included an updated definition, classifications, mechanisms, comorbidities, and recommendations for diagnosis and treatment for LAR, as well as the defined research areas for future evidence-based studies. LAR is a localised nasal allergic response in the absence of systemic atopy characterised by local production of specific IgE (sIgE) antibodies, a TH2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response, with the release of inflammatory mediators. The localised allergic response of LAR is an important topic for the study of allergies. This review provides an update on the current knowledge of LAR.



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