Alcoholic liver disease: Focus on prodromal gut health

Abstract

Alcohol-related liver disease is implicated in gut disturbances, both functionally and structurally. The gut-liver interaction has been noticed as an important feature of the prevention of systemic inflammation as well as liver health. Optimal functioning of the gut-liver axis depends on gut health. Therefore, gut problems could be important for estimating future liver inflammation, while alcoholic liver disease could also provide insight into gut health. Gut problems accompanied by alcoholic liver disease include gut motility and absorption problems, mucosal damage and gut microbiota dysbiosis, and gastrointestinal carcinogenesis. Moreover, emerging evidence supports that besides direct inflammatory injury caused by alcohol, gut problems related to alcoholic liver disease carry out a crucial role for the pathogenesis of cardiovascular and immunological disorders. In this regard, we should consider alcoholic liver disease in the aspect of both gut health and chronic systemic low-grade inflammation. Accordingly, integrative therapeutic strategies are warranted for treating and preventing alcoholic liver disease and systemic inflammation as well as alcohol-related gut problems.

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