Reduced afferent-induced facilitation of primary motor cortex excitability in restless legs syndrome

• Restless legs syndrome (RLS) features both motor and sensory symptoms (primarily in the evening).• The perturbation of sensorimotor integration in RLS does not follow a circadian rhythm.• Patients with RLS show low levels of afferent-induced facilitation.• RLS might result indirectly from a disorder of cortical sensorimotor integration.

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