Motor Unit Number Estimation Based on High-Density Surface Electromyography Decomposition

Motor unit number estimation (MUNE) techniques are clinically useful by estimating the number of functioning motor units in a muscle, which can serve as a biomarker for the progression of motor neuron diseases or neuromuscular disorders. Various MUNE methods have been developed since the incremental counting technique was introduced in 1971 (McComas et al., 1971). The main limitation with the incremental counting technique is the problem known as "alternation", which leads to an erroneous overestimation of the MUNE.

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