c-MET-mediated resistance to EGFR inhibitors in head and neck cancer: How to move from bench to bedside

Mesenchymal–epithelial transition factor (c-MET), found on melanocytes, endothelial cells, and epithelial tissues, is a membrane spanning receptor tyrosine kinase for hepatocyte growth factor (HGF), produced by elements of mesenchymal origin. The receptor-ligand pair controls diverse biological activities including cell proliferation, motility, invasiveness, morphogenesis, apoptosis, and angiogenesis. Consequently, aberrant signal transduction may trigger tumorigenesis with the acquisition of invasive and metastatic phenotypes.

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