Association between Helicobacter pylori infection and metabolic syndrome: A systematic review and meta-analysis.

Abstract

Aim

To systematically review and quantify the effect of Helicobacter pylori (H. pylori) infection on the risk of metabolic syndrome and metabolic parameters in individuals with H. pylori infection.

Methods

A systematic search was performed. Inclusion criteria were observational studies assessing association between H. pylori infection and metabolic syndrome in adult participants. We calculated pooled effect estimate of metabolic syndrome with 95% confidence intervals (CI) comparing between group of H. pylori infection and non-infection by using random-effects model. The secondary outcomes were the difference in homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride, high-density lipoprotein (HDL), fasting blood glucose (FBG), body mass index and systolic blood pressure (SBP).

Results

Eighteen trials comprising 27,544 participants met the inclusion criteria. Six trials were included in the data analysis of metabolic syndrome. There was a statistically significant association between H. pylori and metabolic syndrome with pooled odds ratio (OR) of 1.34 (95% CI: 1.17 to 1.53, I² = 39%, P_{heterogeneity} < 0.01). Between the infected and non-infected groups, there were significant differences in FBG, HDL, body mass index, triglyceride, HOMA-IR and SBP (all P < 0.05).

Conclusion

H. pylori infection is positively associated with metabolic syndrome. Infection with H. pylori is also associated with higher triglyceride, FBG, body mass index, HOMA-IR, SBP and lower HDL.

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