Τρίτη 31 Μαΐου 2016

Lidocaine Tinnitus

In the United States, up to 35 percent of adults will experience an episode of tinnitus. Although most cases of tinnitus are temporary, chronic tinnitus can be incapacitating, making it difficult for you to function and hear the sounds that you want to hear. If you suffer from worsening volume of tinnitus, lidocaine tinnitus may be a solution for you.

Who Qualifies for Lidocaine Tinnitus?
Lidocaine is a way to treat chronic tinnitus that has been worsening over a period of 4 to 8 weeks or longer. Lidocaine would not be used to treat temporary tinnitus. About 8 percent of people have chronic tinnitus and would be under consideration for treatment with lidocaine. Your doctor may evaluate your symptoms and perform some tests such as an EKG to check for abnormal heart rhythms and a hearing exam to check for worsening hearing loss to make sure that you are healthy enough to receive lidocaine tinnitus.

How Lidocaine for Tinnitus Works
Lidocaine for tinnitus is administered intravenously. The medication is added to a saline solution in an intravenous solution bag and delivered to you through a vein. The medication takes 30 to 60 minutes to get into your body. Once the lidocaine is absorbed into your body, it works to numb the nerve endings in your auditory system. When the nerve endings are less stimulated, you will experience a lessening of the volume of your tinnitus. The lidocaine may also reduce hyperactivity of the nerves within your ears. Your normal sense of hearing will not be diminished due to the lidocaine. Some doctors will treat you with a single IV of lidocaine every couple of months to prevent your symptoms from worsening. Other doctors will give you IV lidocaine once per day for a few consecutive days to eliminate tinnitus symptoms.

Benefits of Lidocaine for Tinnitus
There are many benefits to using lidocaine for incapacitating tinnitus symptoms. Lidocaine is generally regarded as safe and has been widely used in dentistry and medicine to provide local anesthesia for minor procedures such as dental fillings or stitches. There is a minimal amount of pain when getting lidocaine for tinnitus. The only pain you are likely to experience is when the IV line is placed. The lidocaine treatment should last for several months, providing you with a long duration of relief from your tinnitus symptoms. Most people experience no side effects from lidocaine injections.




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Speech Perception in Classroom Acoustics by Children With Cochlear Implants and With Typical Hearing

Purpose
This study measured speech perception ability in children with cochlear implants and children with typical hearing when listening across ranges of reverberation times (RTs) and speech-to-noise ratios.
Method
Participants listened in classroom RTs of 0.3, 0.6, and 0.9 s combined with a 21-dB range of speech-to-noise ratios. Subsets also listened in a low-reverberant audiological sound booth. Performance measures using the Bamford-Kowal-Bench Speech-in-Noise Test (Etymotic Research, Inc., 2005) were 50% correct word recognition across these acoustic conditions, with supplementary analyses of percent correct.
Results
Reduction in RT from 0.9 to 0.6 s benefited both groups of children. A further reduction in RT to 0.3 s provided additional benefit to the children with cochlear implants, with no further benefit or harm to those with typical hearing. Scores in the sound booth were significantly higher for the participants with implants than in the classroom.
Conclusions
These results support the acoustic standards of 0.6 s RT for children with typical hearing and 0.3 s RT for children with auditory issues in learning spaces (≤283 m3) as specified in standards S12.60-2010/Part 1 of the American National Standards Institute /Acoustical Society of America (2010). In addition, speech perception testing in a low-reverberant booth overestimated classroom listening ability in children with cochlear implants.

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Save Your Hearing Day

May 31 ends Better Hearing and Speech Month with National #SaveYourHearingDay. It is important to take some time to learn ways to protect your hearing and that of your family. Our hearing is vital, and there are ways that hearing loss can be avoidable.

There are various reasons from which hearing loss can be the result, including the following:



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Double amputation can't stop paramedic quest

Minutes after waking up from a medically induced coma Noah Filer asked his girlfriend Jenni two important questions.

His first question to Jenni, now his wife, was, "Where in the hell are my arm and leg?"

He says he took a minute to process the loss of his arm and leg and then asked his second question, "What about my paramedic?"

Four weeks earlier, April 1, 2012, Filer had been in a serious motorcycle collision that resulted in a traumatic brain injury and the loss of his left arm and left leg.

Eager to learn
Filer, now 27 and licensed paramedic, can't recall what specifically caused him to join the Durand (Ill.) Fire Department in 2007, but he quickly realized that if he wanted a radio he needed to become an EMT. He completed EMT training in the fall of 2008 and responded to as many calls as he could when he wasn't working at a Lowes' distribution center.

"I worked 12-hour shifts Friday, Saturday, Sunday so I was always willing to go to calls on Monday through Thursday," Filer said. "I was going to calls to learn as much as I could."

As he gained experience, Filer got a full-time EMT position on the Durand ambulance. After four years of EMT work, Filer set his sights on a paramedic license to better his chances of joining the Rockford (Ill.) Fire Department.

Launching a firefighter-paramedic career
Filer started the SwedishAmerican hospital 12-month paramedic program in August 2011. The accredited program starts with nine months of didactic lectures, skills instruction, clinical experiences and is followed by an ambulance ride-time internship.

The SwedishAmerican paramedic students meet two days a week from August to May. Tonja Radford, paramedic, lead instructor and clinical coordinator recalls Filer as "very good student" in the 2011-2012 student cohort.

Paramedic class, even the challenges of anatomy and physiology, was coming together well for Filer. "I was busting my butt on clinical hours, class and still working full time," he said about the weeks leading up to his accident. "I was working hard and not having any problems with paramedic class," which had just started the trauma section of lectures and skills.

Mom had a bad feeling
On April 1, 2012, Filer finished his Durand EMT shift at 8 a.m. He went home to change clothes before leaving with a friend to buy his first motorcycle.

Before leaving the house, his mom warned him she had bad feeling about him buying a motorcycle. That morning he rode a used motorcycle — his first time on a bike — in the farmyard with his friend Jeff. The pair decided to ride to Rockford, about 20 miles away.

Filer's last memory of that morning is gassing up the motorcycle in Durand.

"Jeff said I reached up to scratch something above my eye. When I did that I crossed the center line and collided head-on with a car."

His injuries were devastating. A Durand ambulance picked him up. Three of his co-workers, two EMTs and a paramedic, cared for him on-scene and en route to the hospital.

"They told me later that I had equal chest rise and fall, no JVD, but they supported with BVM," Filer said of his injuries. "They described my leg as foot backwards pointing towards head, femur broken mid-shaft with arterial bleeding, and left thumb almost amputated from the impact."

He was wearing a helmet, but was unconscious. "My blood pressure was around 200 and I alternated between decerebrate posturing and seizures in the ambulance."

Trauma care and amputations
Filer was in a coma for about four weeks as decisions were made and acted upon to replace his femur with a rod, amputate his left leg below the knee, and amputate his left arm above the elbow.

Noah Filer Paramedic ICU

Noah Filer in the ICU three days after his motorcycle accident

"I have half a tricep and half a bicep," Filer says of his left arm.

After the surgeries — 17 all tolled — and a multi-week stay in the trauma ICU, Filer was transferred to a rehab center.

Noah Filer Paramedic Post Op left leg

Close-up of Filer's left leg and knee after surgery

Nine days after the crash, Filer gave his first purposeful hand squeeze. It took four weeks for him to speak his first words and be moved out of the ICU. On May 10, he moved to the rehab center. It was there that he woke from the coma and declared his desire to finish his paramedic certification.

Filer didn't go home on June 6 because he was ready, but because he was adamant to not miss an annual fishing trip with his grandfather. Instead of going AMA, he was discharged and had a successful family fishing trip using an electric reel given to him by his cousin.

Noah Filer Paramedic Fishing Trip

Filer refused to miss an annual family fishing trip just two months after his motorcycle collision

60-hours and several years left to paramedic
Before the accident Filer didn't stand out to Dr. John Underwood any more than the other students. "When I was called to visit him at the rehab center, I learned he was the top student in his class, way ahead on clinical and ahead of expectations," Underwood said.

Underwood, the medical director for the SwedishAmerican paramedic education program, visited with Filer in the rehab center. He was unsure what to expect from a young man that had been severely injured and in very tenuous condition while hospitalized.

"Underwood told me I had 60 hours left of clinical and I was doing academically better than anyone else in the class," Filer recalls of Underwood's visit. "He told me he would 'do whatever it takes' because of all the hard work I had done."

But it would be several years before Filer was able to complete his clinical time. The process of fitting prosthetics, learning to use a body-powered harness to open his left hand prosthesis and rehab injured muscles was grueling.

Noah Filer Paramedic Rehab

Filer wearing an above the knee prosthetic leg

Testing cognitive and kinesthetic domains
EMS instruction is often categorized into three domains: cognitive, kinesthetic and affective. Filer had been excelling in all three before his accident.

Tom Pratt, SwedishAmerican EMS manager, described the need for Filer to do all the things expected of a paramedic with only reasonable accommodations. Filer completed all sorts of testing to see his adaptability to succeed with the right equipment and resources, Pratt said.

One of the ways his caregivers and paramedic instructors tested Filer's brain function — performance in the cognitive domain — was by reviewing his paramedic textbook and retaking course tests. The paramedic textbook was also useful for reading and speech-related rehabilitation.

"The most effort (to pass the tests) had to come from him," Radford said of Filer's progress and drive to finish his paramedic course.

Filer rejoined Radford's paramedic class in January 2013. To everyone's surprise and relief Filer, a top student before the accident, did as well or better on the tests he retook. He was able to recall information he previously studied, learn new information and apply that information on examinations.

Eligibility and accommodations
While Filer was rehabbing, Underwood went to work on determining the eligibility of a double amputee to become a paramedic in Illinois and advocating on Filer's behalf with the Illinois Department of Public Health.

Although the IDPH initially requested that Filer be evaluated for his physical ability, Underwood determined there was no statutory or regulatory authority for Filer's physical ability to be evaluated. All that was required was Filer's completion of a paramedic training program — making him eligible for the IDPH written paramedic examination — and successfully passing the exam.

The Americans with Disabilities Act prohibits discrimination against people with disabilities in employment, transportation, public accommodation, communication and governmental activities. One of the ADA's key provisions is that employers make a reasonable adjustment to a job or work requirement to make it possible for an individual with a disability to perform a job duty.

To complete his paramedic, Filer who is right handed, had two significant kinesthetic skills to demonstrate competency — endotracheal intubation and intravenous cannulation. "We were waiting on the prosthetic leg, then arm at the end of the didactic class to figure out ways to do the hands-on skills," Radford said.

Filer had three endotracheal intubations still to perform. He got an airway manikin and airway kit to practice on his own. "I had to learn how to position my body to open my left hand using the body-powered harness," Filer said.

Despite learning how to position his body to manipulate the harness, he could not securely hold a laryngoscope handle to perform direct laryngoscopy.

"The left hand couldn't hold the laryngoscope," Filer said. "The hand would slip and I would pry (the manikin's jaw). It was not good airway control."

Video laryngoscopy emerged as a reasonable accommodation for Filer. "The screen on a video laryngoscope kept the handle from sliding through my hand."

Equipped with a VL system purchased with a grant from the SwedishAmerican Health System Foundation, and accompanied by Underwood, Filer went to the operating room to complete his three intubations.

Noah Filer Paramedic Video Laryngoscope

Filer's left hand prosthesis holding a King Vision video laryngoscope as he prepares to intubate a manikin

"I tagged along to see if there were any concerns with Noah's one handedness in the OR," Underwood said. "But it was quickly obvious he was doing fine."

"I was able to get four intubations and could have gotten more, but I only had four of the disposable (VL) blades for the laryngoscope," Filer said.

One of the patients presented a difficult airway to Filer. "The patient had a swollen epiglottis," Filer said. He could not pass the endotracheal tube. Without taking his eyes off the vocal cords he used a bougie and then slid the ET tube over the bougie.

Finding his own job accommodations
Many of the steps of intravenous access can be performed with a single hand. As Filer completed his clinical time he couldn't tie a tourniquet with just his right hand and his prosthetic left hand couldn't be manipulated to complete the task.

"I went online and found a one-handed, reusable tourniquet," Filer said. "I bought one, for a few dollars, tried it and it worked." Filer now has a pack of the reusable tourniquets that he can secure single handed.

As Filer's instructor Radford knows, there are multiple ways to perform patient assessment and treatment procedures. "How else can we do this," Radford encourages other instructors to ask to help students with disabilities find other ways to get things done.

Filer wrapped up his clinical time with three days at the hospital for pediatric and obstetric patient contacts. He did the remaining hours on the ambulance with preceptors who he said were "helpful and encouraging."

Patients on the ambulance didn't have any problem with a paramedic student who also had a prosthetic. "I offered it up to patients," Filer said.

"He passed everything we were asking of everyone else," Radford said. "Just like all the other students."

Master of the affective domain
Those who have worked with and taught Filer are quick to mention his mastery of the affective domain. His positive attitude, always smiling demeanor, sense of humor and willingness to help others have always set him apart.

"I am proud to have Noah as a co-worker," said Pratt, who has been a nurse for 30 years. "Noah said he was going to 'keep at it — adapt and overcome,' which he has done."

"He has drive. (Filer) is more than willing for work it," Radford said. "He told me, 'You can take half my body, but you can't take my will.'"

Radford and other instructors appreciated Filer's jokes and sense of humor just as much after the accident as they did before his injury.

"I tell people I am always a guy to help out," Filer quipped. "In fact I am glad to give a hand — my left hand — to anyone that needs it."

Another of Filer's go-to jokes to put others at ease plays on his health care knowledge. "If I ever have diabetes mellitus and need an amputation I want them to take my left leg first."

Final written test to be a paramedic
With his clinical time complete, Filer passed the SwedishAmerican paramedic course. In Illinois, paramedic students can choose the Illinois State Licensing Exam or the National Registry Exam. In early 2016 Filer took the Illinois computer-based test.

Filer's originally chose the SwedishAmerican 12-month program because it was fast and convenient. Now almost five years after he started he was determined to become a paramedic. "I put in so much time and effort," Filer said.

But it wasn't enough. He didn't pass the exam on his first attempt.

After that setback Filer realized he needed to do even more to get ready. "I spent 105 hours using EMTPrep.com and passed the IDPH written exam on March 28, 2016."

On the job and back home
Since receiving his paramedic certification, Filer has worked as an emergency department clinical greeter at SwedishAmerican three days a week. During his 12-hour shifts, he greets patients in the waiting room, assesses the nature of their illness, triages patients to be seen immediately, begins the registration process and reassesses patients who are waiting to be seen.

Although he is still on the roster at Durand, Filer doesn't think becoming a firefighter-paramedic is "in the cards." He recently celebrated his daughter's second birthday and likes the flexibility that comes with working three 12-hours shifts a week with four days off to spend with his family. 

"Everyone has good days, bad days," Filer says about learning to live with prostheses. "If there is pain it is a fit issue."

Filer says he has an awesome prosthetist who helps makes sure the fit is good and he has the right size prosthetic to meet the demands of his job, which includes lifting and moving patients.

Filer regularly works out and lifts weights. He is able to squat lift 350 pounds and dead lift 250 pounds so he needed a leg prosthetic that could accept a load of at least 475 pounds — his body weight plus his maximum squat lift.

If Filer decides to seek work on an ambulance, Radford would not hesitate to have him as a partner. She also noted that all paramedics, including those who are able- or full-bodied frequently call for help lifting or treating patients.

For aspiring paramedics who are also amputees Filer's advice from his experience is to "stay patient and keep working." 



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Clinical and molecular heterogeneity of head and neck spindle cell and sclerosing rhabdomyosarcoma

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Spindle cell and sclerosing rhabdomyosarcoma (sRMS/scRMS) accounting for 5–10% of all RMS, were recently reclassified as a stand-alone pathologic entity in the latest WHO classification of soft tissue tumors [1]. Spindle cell RMS was first described by the German–Italian Cooperative Sarcoma Study on the basis of its distinct clinicopathologic features and favorable outcome, resulting in separation from the more common embryonal RMS (ERMS) [2]. Sclerosing RMS was first defined by Mentzel and Katenkamp as a 'sclerosing pseudovascular RMS in adults' [3].

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Induction chemotherapy for head and neck squamous cell carcinoma

A population-based study [1] and two meta-analyses [2,3] have recently addressed the controversial topic of induction chemotherapy (IC) before concurrent chemoradiotherapy (CRT) versus CRT alone for locally advanced head and neck squamous cell carcinoma.

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The dissociability of lexical retrieval and morphosyntactic processes for nouns and verbs: A functional and anatomoclinical study

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Publication date: August 2016
Source:Brain and Language, Volume 159
Author(s): Annalisa Benetello, Chiara Finocchiaro, Rita Capasso, Erminio Capitani, Marcella Laiacona, Stefano Magon, Gabriele Miceli
Nouns and verbs can dissociate following brain damage, at both lexical retrieval and morphosyntactic processing levels. In order to document the range and the neural underpinnings of behavioral dissociations, twelve aphasics with disproportionate difficulty naming objects or actions were asked to apply phonologically identical morphosyntactic transformations to nouns and verbs.Two subjects with poor object naming and 2/10 with poor action naming made no morphosyntactic errors at all. Six of 10 subjects with poor action naming showed disproportionate or no morphosyntactic difficulties for verbs. Morphological errors on nouns and verbs correlated at the group level, but in individual cases a selective impairment of verb morphology was observed.Poor object and action naming with spared morphosyntax were associated with non-overlapping lesions (inferior occipitotemporal and fronto-temporal, respectively). Poor verb morphosyntax was observed with frontal-temporal lesions affecting white matter tracts deep to the insula, possibly disrupting the interaction of nodes in a fronto-temporal network.



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Cover 2: Editorial Board

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Publication date: June–July 2016
Source:Brain and Language, Volumes 157–158





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Induction chemotherapy for head and neck squamous cell carcinoma

Publication date: Available online 30 May 2016
Source:Oral Oncology
Author(s): James T. Parsons, Bruce D. Greene




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Clinical and molecular heterogeneity of head and neck spindle cell and sclerosing rhabdomyosarcoma

Publication date: Available online 31 May 2016
Source:Oral Oncology
Author(s): Adepitan A. Owosho, Sonja Chen, Shruti Kashikar, Lei Zhang, Chun-Liang Chen, Leonard H. Wexler, Cherry L. Estilo, Joseph M. Huryn, Cristina R. Antonescu




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Impact of peripheral hearing loss on top-down auditory processing

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Publication date: Available online 31 May 2016
Source:Hearing Research
Author(s): Alexandria M.H. Lesicko, Daniel A. Llano
The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory structures. However, hearing loss-induced changes in descending connections that emanate from higher auditory centers and project back toward the periphery are still poorly understood. These pathways, which are the hypothesized substrate of high-level contextual and plasticity cues, are intimately linked to the ascending stream, and are thereby also likely to be influenced by auditory deprivation. In the current report, we review both the human and animal literature regarding changes in top-down modulation after peripheral hearing loss. Both aged humans and cochlear implant users are able to harness the power of top-down cues to disambiguate corrupted sounds and, in the case of aged listeners, may rely more heavily on these cues than non-aged listeners. The animal literature also reveals a plethora of structural and functional changes occurring in multiple descending projection systems after peripheral deafferentation. These data suggest that peripheral deafferentation induces a rebalancing of bottom-up and top-down controls, and that it will be necessary to understand the mechanisms underlying this rebalancing to develop better rehabilitation strategies for individuals with peripheral hearing loss.



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A cool approach to reducing electrode-induced trauma: localized therapeutic hypothermia conserves residual hearing in cochlear implantation

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Publication date: Available online 31 May 2016
Source:Hearing Research
Author(s): Ilmar Tamames, Curtis King, Esperanza Bas, W. Dalton Dietrich, Fred Telischi, Suhrud M. Rajguru
ObjectiveThe trauma caused during cochlear implant insertion can lead to cell death and a loss of residual hair cells in the cochlea. Various therapeutic approaches have been studied to prevent cochlear implant-induced residual hearing loss with limited success. In the present study, we show the efficacy of mild to moderate therapeutic hypothermia of 4 to 6ºC applied to the cochlea in reducing residual hearing loss associated with the electrode insertion trauma.ApproachRats were randomly distributed in three groups: control contralateral cochleae, normothermic implanted cochleae and hypothermic implanted cochleae. Localized hypothermia was delivered to the middle turn of the cochlea for 20 minutes before and after implantation using a custom-designed probe perfused with cooled fluorocarbon. Auditory brainstem responses (ABRs) were recorded to assess the hearing function prior to and post-cochlear implantation at various time points up to 30 days. At the conclusion of the trials, inner ears were harvested for histology and cell count. The approach was extended to cadaver temporal bones to study the potential surgical approach and efficacy of our device. In this case, the hypothermia probe was placed next to the round window niche via the facial recess or a myringotomy.Main ResultsA significant loss of residual hearing was observed in the normothermic implant group. Comparatively, the residual hearing in the cochleae receiving therapeutic hypothermia was significantly conserved. Histology confirmed a significant loss of outer hair cells in normothermic cochleae receiving the surgical trauma when compared to the hypothermia treated group. In human temporal bones, a controlled and effective cooling of the cochlea was achieved using our approach.SignificanceCollectively, these results suggest that therapeutic hypothermia during cochlear implantation may reduce traumatic effects of electrode insertion and improve conservation of residual hearing.



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Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study

Here, we aim to identify cortical electrofunctional correlates of responsiveness to short-lasting preventiveintervention with ketogenic diet (KD) in migraine.

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The use of a modified abbé island flap to reconstruct primary lip defects of over 80 %

Abstract

Background

Lip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to defects under 65 %.

Methods

We describe a two-stage "modified Abbé island flap" technique whereby a full-thickness myocutaneous flap is combined with a modified Karapandzic flap, allowing for reconstruction of total and near total lip defects.

Results

Six patients underwent successful two-stage lower and upper lip reconstruction with this technique. Oral competence and satisfactory aesthetic outcomes were achieved in all six cases. There were no complications. Although microstomia was noted to a certain extent, we argue this impact to be less than the morbidity of a free flap that lacks sphincteric function.

Conclusion

The "Modified Abbé Island Flap" can be used to reconstruct near-total lip defects using locally innervated, well-vascularized tissues that recreate the oral sphincter and restore oral competence. The combination of the conventional Abbé flap with a modified Karapandzic flap provides reliable results and significantly reduces operating time.



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Shared decision-making in pediatric otolaryngology: Parent, physician and observational perspectives

Publication date: August 2016
Source:International Journal of Pediatric Otorhinolaryngology, Volume 87
Author(s): Paul Hong, Erin Maguire, Ayala Y. Gorodzinsky, Janet A. Curran, Krista Ritchie, Jill Chorney
ObjectiveTo describe physician and parent behavior during pediatric otolaryngology surgical consultations, and to assess whether perceptions of shared decision-making and observed behavior are related.MethodsParents of 126 children less than 6-years of age who underwent consultation for adeontonsillectomy or tympanostomy tube insertion were prospectively enrolled. Parents completed the Shared Decision-Making Questionnaire-Patient version (SDM-Q-9), while surgeons completed the Shared Decision-Making Questionnaire-Physician version (SDM-Q-Doc) after the consultation. Visits were video-recorded and analyzed using the Roter Interaction Analysis System to quantify physician and parent involvement during the consultation.ResultsPerceptions of shared decision-making between parents (SDM-Q-9) and physicians (SDM-Q-Doc) were significantly positively correlated (p = 0.03). However, there was no correlation between parents' perceptions of shared decision-making and observations of physician and parent behavior/involvement (proportion of physician socioemotional talk, task-focused talk, or proportion of parent talk). Surgeons' perceptions of shared decision-making were correlated with physician task-focused talk and proportion of parent talk.ConclusionsParents and physicians had similar perceptions of the degree of shared decision-making to be taking place during pediatric otolaryngology consultations. However, there was variability in the degree to which parents participated, and parent perceptions of shared decision-making were not correlated with actual observed involvement.



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The effect of the leukotriene antagonist pranlukast on pediatric acute otitis media

Publication date: August 2016
Source:International Journal of Pediatric Otorhinolaryngology, Volume 87
Author(s): Yoshihisa Nakamura, Yuki Hamajima, Motohiko Suzuki, Shinichi Esaki, Makoto Yokota, Masanori Oshika, Ippei Takagi, Keiko Yasui, Naoya Miyamoto, Kazuko Sugiyama, Meiho Nakayama, Shingo Murakami
ObjectiveConventional treatment for acute otitis media mainly targets bacteria with antibiotics, neglecting to control for mediators of inflammation. Mediators of inflammation, such as leukotrienes, have been identified in patients with acute otitis media (AOM) or subsequent secretory otitis media (SOM). They can cause functional eustachian tube dysfunction or increase mucous in the middle ear, causing persistent SOM following AOM. The objective of the present study was to evaluate whether or not administration of pranlukast, a widely used leukotriene C4, D4, and E4 antagonist, together with antibiotics could inhibit the progression to SOM.MethodsChildren with AOM, who were from two to 12 years old, were randomly divided into two groups as follows: a control group in which 50 patients received antibiotic-based conventional treatment according to guidelines for treating AOM proposed by the Japan Otological Society (version 2006); and a pranlukast group, in which 52 patients were administered pranlukast for up to 28 days as well as given conventional treatment. Cases were regarded as persistent SOM when a tympanogram was type B or C2 four weeks after treatment was initiated.ResultsTwo patients in the pranlukast group and 3 patients in the control group were excluded because they relapsed AOM within 28 days after initial treatment. Therefore, the analysis included 50 and 47 subjects in the pranlukast and control groups, respectively. The percentage of patients diagnosed with persistent SOM (22.0%) was significantly smaller in the pranlukast group compared with the control group (44.7%) (p = 0.018, chi-squared test).ConclusionThe results indicate that combined treatment of AOM with antibiotics and a leukotriene antagonist to control inflammation is useful for preventing progression to persistent SOM.



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Time-domain comparisons of power law attenuation in causal and noncausal time-fractional wave equations

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The attenuation of ultrasound propagating in human tissue follows a power law with respect to frequency that is modeled by several different causal and noncausal fractional partial differential equations. To demonstrate some of the similarities and differences that are observed in three related time-fractional partial differential equations, time-domain Green's functions are calculated numerically for the power law wave equation, the Szabo wave equation, and for the Caputo wave equation. These Green's functions are evaluated for water with a power law exponent of y = 2, breast with a power law exponent of y = 1.5, and liver with a power law exponent of y = 1.139. Simulation results show that the noncausal features of the numerically calculated time-domain response are only evident very close to the source and that these causal and noncausal time-domain Green's functions converge to the same result away from the source. When noncausal time-domain Green's functions are convolved with a short pulse, no evidence of noncausal behavior remains in the time-domain, which suggests that these causal and noncausal time-fractional models are equally effective for these numerical calculations.



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Acoustic scattering from phononic crystals with complex geometry

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This work introduces a formalism for computing external acoustic scattering from phononic crystals (PCs) with arbitrary exterior shape using a Bloch wave expansion technique coupled with the Helmholtz-Kirchhoff integral (HKI). Similar to a Kirchhoff approximation, a geometrically complex PC's surface is broken into a set of facets in which the scattering from each facet is calculated as if it was a semi-infinite plane interface in the short wavelength limit. When excited by incident radiation, these facets introduce wave modes into the interior of the PC. Incorporation of these modes in the HKI, summed over all facets, then determines the externally scattered acoustic field. In particular, for frequencies in a complete bandgap (the usual operating frequency regime of many PC-based devices and the requisite operating regime of the presented theory), no need exists to solve for internal reflections from oppositely facing edges and, thus, the total scattered field can be computed without the need to consider internal multiple scattering. Several numerical examples are provided to verify the presented approach. Both harmonic and transient results are considered for spherical and bean-shaped PCs, each containing over 100 000 inclusions. This facet formalism is validated by comparison to an existing self-consistent scattering technique.



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Editorial Board

Publication date: July 2016
Source:International Journal of Pediatric Otorhinolaryngology, Volume 86





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In-air hearing of a diving duck: A comparison of psychoacoustic and auditory brainstem response thresholds

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Auditory sensitivity was measured in a species of diving duck that is not often kept in captivity, the lesser scaup. Behavioral (psychoacoustics) and electrophysiological [the auditory brainstem response (ABR)] methods were used to measure in-air auditory sensitivity, and the resulting audiograms were compared. Both approaches yielded audiograms with similar U-shapes and regions of greatest sensitivity (2000−3000 Hz). However, ABR thresholds were higher than psychoacoustic thresholds at all frequencies. This difference was least at the highest frequency tested using both methods (5700 Hz) and greatest at 1000 Hz, where the ABR threshold was 26.8 dB higher than the behavioral measure of threshold. This difference is commonly reported in studies involving many different species. These results highlight the usefulness of each method, depending on the testing conditions and availability of the animals.



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Paediatric Cochlear Implantation in Patients with Waardenburg Syndrome

Objective: To analyse the benefit of cochlear implantation in young deaf children with Waardenburg syndrome (WS) compared to a reference group of young deaf children without additional disabilities. Method: A retrospective study was conducted on children with WS who underwent cochlear implantation at the age of 2 years or younger. The post-operative results for speech perception (phonetically balanced standard Dutch consonant-vocal-consonant word lists) and language comprehension (the Reynell Developmental Language Scales, RDLS), expressed as a language quotient (LQ), were compared between the WS group and the reference group by using multiple linear regression analysis. Results: A total of 14 children were diagnosed with WS, and 6 of them had additional disabilities. The WS children were implanted at a mean age of 1.6 years and the 48 children of the reference group at a mean age of 1.3 years. The WS children had a mean phoneme score of 80% and a mean LQ of 0.74 at 3 years post-implantation, and these results were comparable to those of the reference group. Only the factor additional disabilities had a significant negative influence on auditory perception and language comprehension. Conclusions: Children with WS performed similarly to the reference group in the present study, and these outcomes are in line with the previous literature. Although good counselling about additional disabilities concomitant to the syndrome is relevant, cochlear implantation is a good rehabilitation method for children with WS.
Audiol Neurotol 2016;21:187-194

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Development of a vestibular schwannoma xenograft zebrafish model for in vivo antitumor drug screening

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Objectives/Hypothesis

The development of a simple, reliable, and cost-effective animal model greatly facilitates disease treatment. We aimed to establish a rapid, simple, and reproducible live zebrafish vestibular schwannoma xenograft model for antitumor drug screening.

Methods

We optimized each of the following conditions for tumor cell xenografts in zebrafish larvae: larval stage, incubation temperature, and injected cell number. We used NF2-/-mouse Schwann (SC4) cells and generated mCherry fluorescent protein-expressing cells prior to injection into zebrafish larvae. SC4 cells were counted using a fluorescence microscope, suspended in 10% fetal bovine serum, and injected into the center of the yolk sac using a microinjection system. The injected embryos were transferred to E3 medium (for zebrafish embryos), and subsequent tumor formation was observed by fluorescence microscopy over a 5-day period. To validate our model, xenografted embryos were transferred into 6-well plates (5 embryos per well) and treated with everolimus, a known antitumor drug.

Results

mCherry fluorescent protein-expressing SC4 cells were successfully grafted into the yolk sacs of zebrafish embryos without any immunosuppressant treatment. At 2 days postinjection, the xenografted cells had grown into tumor masses. The optimal speed of tumor formation depended on the larval stage (30 hpf), incubation temperature (31°C), and injected cell number (200 cells). In preliminary tests, everolimus treatment yielded a > 20% reduction in the number of SC4 cells in the yolk.

Conclusion

Our in vivo model has the potential to greatly facilitate vestibular schwannoma treatment because of its speed, simplicity, reproducibility, and amenability to live imaging.

Level of Evidence

N/A. Laryngoscope, 2016



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Exploring Methods to Measure the Prevalence of Ménière's Disease in the US Clinformatics™ Database, 2010-2012

Recent studies on the epidemiology of the inner-ear disorder Ménière's disease (MD) use disparate methods for sample selection, case identification and length of observation. Prevalence estimates vary geographically from 17 to 513 cases per 100,000 people. We explored the impact of case detection strategies and observation periods in estimating the prevalence of MD in the USA, using data from a large insurance claims database. Using case detection strategies of ≥1, ≥2 and ≥3 ICD-9 claim codes for MD within a 1-year period, the 2012 prevalence estimates were 66, 27 and 14 cases per 100,000 people, respectively. For ≥1, ≥2 and ≥3 insurance claims within a 3-year observation period, the prevalence estimates were 200, 104 and 66 cases per 100,000 people, respectively. Estimates based on a single claim are likely to overestimate prevalence; this conclusion is aligned with the American Academy of Otolaryngology-Head and Neck Foundation criteria requiring ≥2 definitive episodes for a definite diagnosis, and it has implications for future epidemiologic research. We believe estimates for ≥2 claims may be a more conservative estimate of the prevalence of MD, and multiyear estimates may be needed to allow for adequate follow-up time.
Audiol Neurotol 2016;21:172-177

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Tinnitus: Evaluation of Intratympanic Injection of Combined Lidocaine and Corticosteroids

Background: Tinnitus is an annoying problem and until now there is no consensus on its treatment. Aims: In this prospective study, we evaluated the effectiveness of intratympanic lidocaine and dexamethasone (ITLD) injections for the management of subjective idiopathic tinnitus (SIT). Methods: Forty patients with SIT attended the Department of Otorhinolaryngology, Tanta University Hospital, Egypt, between May 2013 and May 2014. The patients were categorized into two groups: group A included 20 patients treated with ITLD injection, and group B included 20 patients treated with intratympanic saline injection as a control. Intratympanic injections were performed four times within 4 weeks in a double-blind manner. At the end of the treatment program, we analyzed the improvement and worsening rates of tinnitus using the following parameters: tinnitus questionnaires, Tinnitus Handicap Index (THI), and loudness matching test. Results: The effectiveness rates of the ITLD group reported in the tinnitus questionnaires, the THI and the loudness matching test were 74.3% in all tests, compared to 26.7, 40.0 and 26.7%, respectively, in the saline group. There was a statistically significant difference between the groups within 2 months after injection. To analyze the therapeutic effect of ITLD on tinnitus of 6 months duration, the improvement rates reported in the tinnitus questionnaires, the THI and the loudness matching test were 78.5% in all tests in the ITLD group, compared to 40.0, 40.0 and 30.0%, respectively, in the saline group. Conclusion: There were statistically significant differences between both groups. ITLD seems to be effective for idiopathic tinnitus.
ORL 2016;78:159-166

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Der operative Honorararzt im Krankenhaus vor dem Aus?

Zusammenfassung

Die Kooperation zwischen niedergelassenem Chirurgen und Krankenhaus im Bereich der plastischen Chirurgie birgt für alle Beteiligten Vorteile. Der Beitrag widmet sich den rechtlichen Rahmenbedingungen für den niedergelassenen Arzt und skizziert die gegenwärtig bestehenden Diskussionen um eine Einbindung als „Honorararzt" anhand von aktuellen Entwicklungen in der Rechtsprechung. Insbesondere die Abgrenzung einer freiberuflichen Tätigkeit von einer abhängigen Beschäftigung kann im Einzelfall schwierig sein. Neben den Problemen mit der Sozialversicherungspflicht ergeben sich aufgrund der jüngsten Entwicklungen zur Etablierung eines Gesetzes zur Bekämpfung der Korruption im Gesundheitswesen zudem Fragen im Hinblick auf die Zuweisung von Patienten gegen Entgelt. Abschließend werden im Nachgang zur sog. Honorararzt-Entscheidung des Bundesgerichtshofs die bestehenden Möglichkeiten zur Liquidation privatärztlicher Leistungen bzw. von Wahlleistungsentgelten durch Honorarärzte oder angestellte Ärzte im Krankenhaus erörtert.



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Phenotype of a Belgian Family With 6p25 Deletion Syndrome

Background:

The 6p25 deletion syndrome is one of the many syndromes with both hearing impairment as well as vision impairment. However, the audiometric characteristics and radiological findings of patients with 6p25 deletions are only scarcely described in literature. This study focused on characterizing the audiometric and radiological features of a Belgian family with a chromosome 6p25 deletion.

Objective:

To evaluate the hearing impairment, audiometric testing and radiological examination of the temporal bones in 3 family members with a 3.4 Mb deletion in chromosome band 6p25.

Results:

All 3 family members demonstrated slowly progressive sensorineural or mixed hearing impairment. Radiologic examination revealed thickened and sclerotic stapes in all patients and a minor internal partition type II of the cochlea in 2 patients.

Conclusion:

There is a significant phenotypic variability within and among families with the 6p25 deletion syndrome. A thorough genotype-phenotype correlation is difficult because of the small number of affected patients and the limited clinical data available. More clinical data of families with 6p25 deletions need to be published in order to create a reliable and precise phenotypic characterization. However, our findings can facilitate counseling of hearing impairment caused by 6p25 deletions.



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Middle Cranial Fossa Dehiscence as an Incidental Finding on CT

Objectives:

This retrospective chart review demonstrates that the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans increases with age.

Methods:

High-resolution temporal bone CT scans, which had been obtained for any otologic complaint, were reviewed independent of all clinical history. Scans showing soft tissue, fluid, trauma, or previous operations were excluded. The CTs from 183 patients (296 ears) were reviewed, blinded for age and body mass index (BMI). The MCF floor was divided into 7 regions and systematically inspected. Ages and BMIs of the patients were subsequently extracted from the medical record.

Results:

Logistic regression analysis confirmed increasing MCF dehiscence with age (P < .05, odds ratio [OR] = 1.07, R = .584). Over all ages (range, 1-88 years; average, 38.5), 32% of MCF floors were dehiscent at any 1 site. For age 60 and over, 55% were dehiscent. The most common sites of MCF dehisence were directly above the malleus head and above the additus ad antrum (35% and 28%, respectively). Superior canal dehiscence (SCD) was seen in 7% of all patients and only in the context of MCF dehiscence. The prevalence of MCF dehiscence increased with age when patients were analyzed by BMI <25, BMI = 25-30, and BMI >30 (P < .003, P < .04, P = .03).

Conclusion:

The increase of middle cranial fossa dehiscence with respect to age is statistically significant. Over all ages, approximately 32% of ears show dehiscence. Over 60 years, approximately 55% show dehiscence. The odds of having dehiscence double with a 10-year difference in age. The most common sites along the MCF floor are in the epitympanum over the malleus head and the additus ad antrum. There was a statistically significant increase in MCF dehiscence with age when patients with equivalent BMIs are compared.



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Δευτέρα 30 Μαΐου 2016

Larynxreflexe und larynxassoziierte Reflexe

Zusammenfassung

Der laryngeale Adduktionsreflex sowie der pharyngoglottale Schlussreflex schützen die Trachea bzw. die tiefen Atemwege vor dem Eindringen von Fremdmaterial. Der laryngeale Exspirationsreflex und der Hustenreflex dienen dazu, bereits in den Kehlkopf eingedrungenes Fremdmaterial wieder kranialwärts zu expedieren. Weitere larynxassoziierte Reflexe bzw. reflexhafte Funktionen sind der Inspirationsreflex, der Schnüffelreflex und der Schluckreflex. In der Klinik hat es sich bei Patienten mit Dysphagie bisher bewährt, den laryngealen Adduktionsreflex orientierend mit Luftimpulsen zu testen. Mit einem Wasserschlucktest kann der Hustenreflex überprüft werden. Der Schnüffelreflex sollte für die Überprüfung der Abduktionsfähigkeit der Stimmlippen genutzt werden. Es wäre wünschenswert, zukünftig diese lebenswichtigen Schutzmechanismen gezielter und genauer zu überprüfen und insbesondere hinsichtlich der prädiktiven Validität zu evaluieren.



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Konkremente und iatrogene Fremdkörper der ableitenden Tränenwege

Zusammenfassung

Hintergrund

Konkremente (Dakryolithen oder Fremdkörper) der ableitenden Tränenwege (TNW) führen zu chronischen Entzündungen und/oder rezidivierenden TNW-Stenosen. Dakryolithen selbst können aber auch durch chronische Entzündungen verursacht werden.

Ziel der Arbeit

Anhand typischer Verläufe werden die klinischen Zeichen, die Lokalisationen und die chirurgischen Möglichkeiten zur Entfernung der Konkremente aus den TNW aufgezeigt.

Methoden

Eine retrospektive Analyse von 1451 TNW-Operationen von 1131 Patienten wurde durchgeführt. Repräsentativ wurden 14 TNW von 11 Patienten retrospektiv in Hinblick auf aktuelle Beschwerden, Voroperationen sowie chirurgische Eingriffe ausgewertet. Zu 3 Patienten liegen histologische Befunde der entfernten Dakryolithen vor. Durch eine genaue Fotodokumentation werden die operativen Vorgehensweisen geschildert.

Ergebnisse

Bei 220 TNW-Operationen (15,2 %) wurden Dakryolithen nachgewiesen, bei 12 (0,8 %) iatrogenes Fremdkörpermaterial.

Bei allen ausgewählten Patienten lag eine schmerzhafte chronische Entzündung der TNW vor, entweder im Bereich des Tränensacks oder der Tränenkanälchen. Bei 10 Patienten wurde der Eingriff allein oder in Kombination mit einem transkanalikulären Endoskopiesystem durchgeführt. Bei 4 Patienten wurde allein durch einen externen Zugang (transkutan/transkonjunktival) operiert. Bezogen auf die gesamte Studienpopulation wurden bei 16,9 % (n = 91) der Dakryozystorhinostomien, bei 14,6 % (n = 77) der Dakryoendoskopien und bei 35,6 % (n = 52) der Kanalikulotomien Dakryolithen gefunden.

Schlussfolgerung

Konkremente der TNW stellen eine wichtige Differenzialdiagnose bei der Behandlung von Tränenabflussstörungen dar. Verschiedene chirurgische Zugangswege sollten zur Therapie vorgehalten und beherrscht werden. Anamnestisch liegen häufig stattgehabte Eingriffe im Bereich der TNW vor.



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Anatomie und Physiologie der ableitenden Tränenwege

Zusammenfassung

Erkrankungen der ableitenden Tränenwege spielen nicht nur für Augenärzte und interventionell tätige Radiologen eine Rolle, sondern auch für HNO-Ärzte, welche die ableitenden Tränenwege endonasal konservativ oder chirurgisch therapieren. Der vorliegende Beitrag gibt, basierend auf dem heutigen Kenntnisstand unter Berücksichtigung eigener Forschungsergebnisse der letzten Jahre sowie klinischer Gesichtspunkte, einen Überblick über das Grundwissen der Tränenwegsanatomie und -physiologie. Dabei fließen funktionelle Aspekte zum Tränentransport sowie embryologische und pathophysiologische Aspekte mit ein.



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Vorbereitung zur Facharztprüfung HNO



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Change in Practice over Four Decades in the Management of Graves’ Disease in Scotland

There is continuing debate on the optimal treatment for Grave's thyrotoxicosis with a resultant variation in clinical practice. The present study aimed to ascertain changes in practice in the treatment of Grave's thyrotoxicosis in Tayside, Scotland, over the past four decades. Methods. The "Scottish automated follow-up register" (SAFUR) was queried to identify all patients treated for Grave's thyrotoxicosis from 1968 to 2007 inclusive. Patients were divided into 4 groups (Groups A to D) according to the decades. Demographic profile, treatment modalities, radioactive iodine (RAI) dose, and recurrence rates were studied and outcomes were compared by test and ANOVA using SPSS v15.0. A value of

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To what extent and why are COPD and Willis-Ekbom disease associated?

Abstract

Aim

Willis-Ekbom disease (RLS/WED) is common in chronic obstructive pulmonary disease (COPD). Patients with RLS/WED have poorer quality of sleep and more fatigue and depressive symptoms. The prevalence of RLS/WED in patients with COPD has been reported to vary between 29.1 and 36.8 %. However, during exacerbation, the prevalence can increase up to 54 %. These rates are higher than those seen in general population. We have not enough knowledge regarding the association between RLS and COPD. In this study, we aimed to determine the frequency of RLS in patients with stable COPD without comorbid conditions. In addition, we also aimed to determine possible related causative factors.

Method

We included 80 COPD patients without comorbid conditions who presented to our outpatient clinic between April 2013 and September 2013 for RLS/WED evaluation. Three cases that have polyneuropathy and one case that refused undergoing electromyography (EMG) examination were excluded from the study. Demographic data, P-A chest X-rays, pulmonary function tests (PFT), biochemical parameters (including hemogram), and dyspnea scales were evaluated for each patient. In addition, the RLS/WED rating scale and Epworth Sleep Scale (ESS) were applied. Further, each patient diagnosed with RLS/WED underwent a detailed neurological examination (performed by a neurologist) and an EMG examination to rule out polyneuropathy.

Results

Out of 76 COPD cases included in our study, 26.3 % (n = 20) were diagnosed with RLS/WED (mean age 60.4 ± 7.5 years, 20 males). The cases with RLS/WED had significantly lower body mass index (BMI) than cases without RLS/WED (p = 0.009). There were no significant differences between cases with and without RLS/WED with respect to PFT, dyspnea scales, and arterial blood gas values. However, ESS was significantly different (p = 0.016). There were no significant differences in RLS/WED scores and mean hs-CRP levels between COPD stages (p = 0.424; p = 0.518, respectively), while ESS was significantly different (p = 0.016). ESS was significantly higher in stage B COPD than in stages A and D (p = 0.005, p = 0.008, respectively). Based on our model, we found that exacerbations and iron binding capacity (UIBC) were predictive factors for RLS/WED (p < 0.100)

Conclusion

RLS/WED is a common disease in cases with stable COPD. Despite our hypothesis suggesting that the prevalence of RLS/WED in COPD is related with systemic inflammation, we did not find a significant association between hs-CRP and COPD cases with RLS/WED. However, we did find that UIBC is a predictive factor for the development of RLS/WED. Nonetheless, further studies are needed to understand the relationships between UIBC, low BMI, and the development of RLS/WED in COPD.



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Ewing Sarcoma of the External Ear Canal

Background. Ewing sarcoma (ES) is a high-grade malignant tumor that has skeletal and extraskeletal forms and consists of small round cells. In the head and neck region, reported localization of extraskeletal ES includes the larynx, thyroid gland, submandibular gland, nasal fossa, pharynx, skin, and parotid gland, but not the external ear canal. Methods. We present the unique case of a 2-year-old boy with extraskeletal ES arising from the external ear canal, mimicking auricular hematoma. Results. Surgery was performed and a VAC/IE (vincristine, adriamycin, cyclophosphamide alternating with ifosfamide, and etoposide) regimen was used for adjuvant chemotherapy for 12 months. Conclusion. The clinician should consider extraskeletal ES when diagnosing tumors localized in the head and neck region because it may be manifested by a nonspecific clinical picture mimicking common otorhinolaryngologic disorders.

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New perspectives on the conservative management of osteoradionecrosis of the mandible: A literature review

Abstract

Over the last decades, several therapeutic options were considered in the treatment of the osteoradionecrosis (ORN) of the mandible, including supportive measures, ultrasound therapy, corticosteroids, hyperbaric oxygen, surgical resection with reconstruction, and, more recently, drugs capable of reversing the fibroatrophic process. Once established, the ORN does not spontaneously disappear and a standard treatment has not yet been defined. The clear clinical effectiveness of hyperbaric oxygen therapy (HBOT) varies according to the literature and there are some economic/logistic issues to be considered; the triplet tocopherol/pentoxifylline/clodronate demands greater evidence from randomized clinical trials and also resilience from the patient, given the long treatment duration and its possible side effects. Controversy around the ideal treatment of the initial stage ORN of the mandible persists. More rigorous randomized prospective trials are essential. The purpose of this article was to review the relevant literature on the physiopathology of ORN of the mandible and discuss the new perspectives of its conservative treatment. © 2016 Wiley Periodicals, Inc. Head Neck, 2016



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Free abdominal fat transfer (FAT) for partial and total parotidectomy defect reconstruction

Objectives/Hypothesis

A variety of techniques have been proposed for reconstruction of the parotidectomy defect. We reviewed our experience with free abdominal fat transfer (FAT) graft reconstruction of parotidectomy defects for benign and malignant disease.

Methods

The medical records of patients who underwent parotidectomy for benign or malignant disease from 2007 to 2015 were retrospectively reviewed.

Results

One hundred and five patients underwent 108 parotidectomies with FAT reconstruction, with bilateral parotidectomy performed in three patients. The majority of patients had benign pathology (71%) and tumors < 3 cm (57%). Prior surgery had been performed in 13 cases (12%) and prior radiation had been performed in three (3%). Superficial parotidectomy was performed in 62 patients (57%) and concurrent elective neck dissection was performed in eight (7%). A facelift incision was utilized in 59 patients (55%). Postoperative radiation was used in 21 patients (19%). Abdominal donor site complications occurred in 11 patients (10%), consisting of hematoma in eight patients (7%) and seroma in three (3%). Parotidectomy wound dehiscence occurred in six cases (6%); all responded to conservative management. There was no association between age, tumor size, comorbidity, smoking status, extent of surgery, incision, or prior radiation on the development of wound complications. Fat transfer graft debulking was required in three patients with persistent overcorrection beyond 6 months postoperatively. No patient demonstrated undercorrection or further FAT resorption beyond 6 months.

Conclusion

Fat transfer reconstruction of the parotidectomy defect is safe and achieves a consistent and predictable long-term cosmetic result.

Level of Evidence

4. Laryngoscope, 2016



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Establishing a danger zone: An anatomic study of the lingual artery in base of tongue surgery

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Objectives/Hypothesis

To contrast the changes in measurement of the hypoglossal/lingual artery neurovascular bundle (HLNVB) to constant surface landmarks in the base of tongue (BOT) during surgically simulated retraction versus resting anatomic position, and to identify a safe zone for BOT robotic surgery to avoid injury to the HLNVB.

Study Design

Human cadaver study.

Methods

Five fresh-frozen head and neck complexes were obtained, and seven HLNVBs were dissected. A microcaliper was used to measure the distance from the HLNVB to constant surface landmarks in resting and surgically simulated positions using a Feyh-Kastenbauer retractor.

Results

Measurements from foramen cecum to palatoglossus muscle (P < 0.042) was significantly different when comparing anatomical to surgically simulated positions. Importantly, the location of the lingual artery in reference to the surface landmarks measured was dramatically altered with tongue retraction. With retraction, the branches of the dorsal lingual artery were not encountered posterior to a horizontal line between midway circumvallate papilla (mCVP).

Conclusion

Measurements of the HLNVB to surface landmarks in the BOT differs significantly between resting and a surgically simulated tongue position. The dorsal branch of the lingual artery seems more superficial in the BOT than previously described. A safe zone may exist posterior to an imaginary horizontal line between mCVP; however, further studies are needed to confirm this.

Level of Evidence

N/A. Laryngoscope, 2016



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Comparison between 4-MV and 6-MV radiotherapy in T1N0 glottic cancer

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Objectives/Hypothesis

The purpose of this study was to report the outcomes of a retrospective consecutive cohort study of patients with T1N0M0 glottic carcinoma treated with 4-MV or 6-MV radiotherapy.

Study Design

Retrospective case–control study.

Methods

This was a retrospective review of all patients with T1N0M0 glottic carcinoma treated with radiotherapy between January 2000 and December 2012 in the Department of Radiation Oncology at National Cancer Center Singapore. A total of 124 patients were included. Clinical endpoints of interest were: local control (LC), overall survival (OS), and disease-specific survival (DSS). Other prognostic factors for LC were also analyzed: age, gender, smoking status, T substage, dose fraction, field size, anterior commissure involvement, total dose, and overall treatment time.

Results

Six-megavolt photon radiotherapy was used in 73 patients and 4-MV photon radiotherapy in 51 patients. Median follow-up was 4.9 years. The 5-year LC and OS were as follows: 4 MV, 91.6% and 83.4%; 6 MV, 88.8% and 82.8%; and the 5-year LC, OS, and DSS for all patients were 90.4%, 83.3%, and 98.3%. There was no significant difference in LR and OS between 4-MV and 6-MV radiotherapy (P = .92, P = .16, respectively). In the univariate analysis of LC, none of the prognostic factors was statistically significant. Twenty patients (23%) developed second primary cancers, the majority in the lungs.

Conclusions

Six-megavolt photon radiotherapy yields comparable results to 4-MV photons. Bolus and computed tomographic simulation are useful to ensure adequate dose coverage of target volume. Follow-up postradiotherapy should incorporate chest imaging, smoking cessation advice, and thyroid function test.

Level of Evidence

4 Laryngoscope, 2016



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Impact of chronic obstructive pulmonary disease on patients undergoing laryngectomy for laryngeal cancer

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Objectives/Hypothesis

Although chronic obstructive pulmonary disease (COPD) is a common comorbidity in patients undergoing laryngeal cancer surgery, the impact of this comorbidity in this setting is not well established. In this analysis, we used the Nationwide Inpatient Sample (NIS) to elucidate the impact of COPD on outcomes after laryngectomy for laryngeal cancer.

Methods

The NIS was queried for patients admitted from 1998 to 2010 with laryngeal cancer who underwent total or partial laryngectomy. Patient demographics, type of admission, length of stay, hospital charges, and concomitant diagnoses were analyzed.

Results

Our inclusion criteria yielded a cohort of 40,441 patients: 3,051 with COPD and 37,390 without. On average, COPD was associated with an additional $12,500 (P < 0.001) in hospital charges and an additional 1.4 days (P < 0.001) of hospital stay. There was no significant difference in incidence of in-hospital mortality between the COPD and non-COPD groups after total laryngectomy (1.1% in COPD vs. 1.0% in non-COPD; P = 0.776); however, there was an increased incidence of in-hospital mortality in the COPD group compared to the non-COPD group after partial laryngectomy (3.4% in COPD vs. 0.4% in non-COPD; P < 0.001). Multivariate adjusted logistic regression revealed that COPD was associated with greater odds of pulmonary complications after both partial laryngectomy (odds ratio [OR] = 3.198; P < 0.001) and total laryngectomy (OR = 1.575; P < 0.001).

Conclusion

Chronic obstructive pulmonary disease appears to be associated with greater hospital charges, length of stay, and postoperative pulmonary complications in patients undergoing laryngectomy for laryngeal cancer. Chronic obstructive pulmonary disease after partial, but not total, laryngectomy appears to be associated with increased risk of in-hospital mortality.

Level of Evidence

2C. Laryngoscope, 2016



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Does melatonin have a meaningful role as a sleep aid for jet lag recovery?

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Pediatric sialoblastoma: Evaluation and management

Publication date: August 2016
Source:International Journal of Pediatric Otorhinolaryngology, Volume 87
Author(s): Alexandria L. Irace, Eelam A. Adil, Natasha M. Archer, Victoria M. Silvera, Antonio Perez-Atayde, Reza Rahbar
ObjectivesSialoblastoma is a rare congenital salivary gland tumor of epithelial origin. The objectives of this study are to review the literature regarding clinical presentation of sialoblastoma, evaluate the effectiveness of various treatment methods, and present guidelines for evaluation and management in the pediatric population.Data sources:Case presentation and literature review.Review methodsA comprehensive search was conducted to identify cases of pediatric sialoblastoma in the English-language literature. The presentation, evaluation, and management of reported cases were analyzed. We also report an invasive and recurrent case in a pediatric patient to highlight the aggressive nature of these lesions.ResultsSixty-two cases of pediatric sialoblastoma were reviewed. The age at initial presentation ranged from before birth to 15 years. The parotid gland was the most common location (n = 47). Surgical excision was the primary treatment in all patients. Nine patients developed metastatic disease of the lung, lymph nodes, or bone. Almost a third of patients had recurrence and over two thirds of patients were tumor-free for at least 1 year following their last treatment intervention.ConclusionPrompt and complete surgical excision should be recommended to prevent local and systemic recurrence of pediatric sialoblastoma. Chemotherapy has also shown promise in several cases, and clinical genomics may shed light on more therapy options. Patients should be closely followed for at least 12 months following diagnosis, or longer depending on the histopathological staging of the tumor.



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Κυριακή 29 Μαΐου 2016

Ferric maltol therapy for iron deficiency anaemia in patients with inflammatory bowel disease: long-term extension data from a Phase 3 study

Summary

Background

Ferric maltol was effective and well-tolerated in iron deficiency anaemia patients with inflammatory bowel disease during a 12-week placebo-controlled trial.

Aim

To perform a Phase 3 extension study evaluating long-term efficacy and safety with ferric maltol in inflammatory bowel disease patients in whom oral ferrous therapies had failed to correct iron deficiency anaemia.

Methods

After 12 weeks of randomised, double-blind treatment, patients with iron deficiency anaemia and mild-to-moderate ulcerative colitis or Crohn's disease received open-label ferric maltol 30 mg b.d. for 52 weeks.

Results

111 patients completed randomised treatment and 97 entered the open-label ferric maltol extension. In patients randomised to ferric maltol ('continued'; n = 50), mean ± s.d. haemoglobin increased by 3.07 ± 1.46 g/dL between baseline and Week 64. In patients randomised to placebo ('switch'; n = 47), haemoglobin increased by 2.19 ± 1.61 g/dL. Normal haemoglobin was achieved in high proportions of both continued and switch patients (89% and 83% at Week 64, respectively). Serum ferritin increased from 8.9 μg/L (baseline) to 26.0 μg/L (Week 12) in ferric maltol-treated patients, and to 57.4 μg/L amongst all patients at Week 64. In total, 80% of patients reported ≥1 adverse event by Week 64. Adverse events considered related to ferric maltol were recorded in 27/111 (24%) patients: 8/18 discontinuations due to adverse events were treatment-related. One patient was withdrawn due to increased ulcerative colitis activity.

Conclusions

Normal haemoglobin was observed in ≥80% of patients from weeks 20–64 of long-term ferric maltol treatment, with concomitant increases in iron storage parameters. Ferric maltol was well-tolerated throughout this 64-week study.



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Σάββατο 28 Μαΐου 2016

Survival Analysis of Veteran Patients with Pancreatic Cancer

Abstract

Background

For patients with pancreatic cancer, the identification of reliable predictors of outcome could be invaluable for directing management.

Aims

The goal of this study was to identify clinical and laboratory factors that predict early versus late mortality.

Methods

Medical records of patients diagnosed with pancreatic cancer in the Dallas VA from 2005 to 2010 were retrospectively reviewed and divided into two groups, early (≤6 months) and late (>6 months) mortality groups. Univariable (UVA) and multivariable analyses (MVA) were performed and the utility of CA 19-9 was explored.

Results

109 patients with pancreatic cancer (89% adenocarcinoma) were divided into early (n = 62) and late (n = 47) mortality groups. Kaplan-Meier analysis revealed median survival of 154 days (95%CI 93-194 days). On MVA, abdominal pain (OR = 10.6, p = 0.009) and larger tumor size (OR = 2.4, p = 0.028) were significantly associated with early mortality, while palliative chemotherapy (OR = 0.048, p = 0.001) and neuroendocrine tumor (OR = 0.009; p = 0.024) were significantly associated with late mortality. Subgroup analysis of adenocarcinoma and late stage patients revealed similar results. Serum CA 19-9 performed poorly as a prognostic indicator in early vs. late mortality groups (p = 0.43), in metastatic disease at diagnosis (p = 0.32) and after treatment (p = 0.65).

Conclusions

Abdominal pain and large tumor size portends poor prognosis in patients with pancreatic cancer. Palliative chemotherapy and surgical intervention may prolong survival. CA 19-9 is not universally reliable for predicting metastasis, survival, or response to chemotherapy.



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Technical note for post-auricular route surgery in Mongolian gerbil

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Publication date: Available online 28 May 2016
Source:Hearing Research
Author(s): Michaël Risoud, Nicolas-Xavier Bonne, Martin Fourdrinier, Thomas Hubert, Christophe Vincent
The Mongolian gerbil (Meriones unguiculatus) is commonly used in hearing research because the hearing frequency spectrum of the gerbil is rather similar to that of the human being. However, a precise description of the surgical post-auricular route has not been reported. The aim of this technical note is to provide details on the procedure and the surgical anatomy of the post-auricular route in the Mongolian gerbil.Surgery was performed under general anesthesia on eight (2 males and 6 females) adult Mongolian gerbils. All steps of the post-auricular route were detailed. This surgery provided an access to the following structures: the semi-circular posterior and lateral canals, the external auditory meatus, the tympanic membrane, the round window, the stapes, the stapedial artery and the reliefs of the cochlea. No anatomic variation was noticed among the 8 animals.This post-auricular route in the Mongolian gerbil defines a brief and simple surgery, overall standardized as a consequence of the absence of common anatomic variation, with painless and uncomplicated post-operative stage.



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A systematic review of the reporting of tinnitus prevalence and severity

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Publication date: Available online 28 May 2016
Source:Hearing Research
Author(s): Abby McCormack, Mark Edmondson-Jones, Sarah Somerset, Deborah Hall
IntroductionThere is no standard diagnostic criterion for tinnitus, although some clinical assessment instruments do exist for identifying patient complaints. Within epidemiological studies the presence of tinnitus is determined primarily by self-report, typically in response to a single question. Using these methods prevalence figures vary widely. Given the variety of published estimates worldwide, we assessed and collated published prevalence estimates of tinnitus and tinnitus severity, creating a narrative synthesis of the data. The variability between prevalence estimates was investigated in order to determine any barriers to data synthesis and to identify reasons for heterogeneity.Methodsand analysis: A systematic review included all adult population studies reporting the prevalence of tinnitus from January 1980 to July 2015. We searched five databases (Embase, Medline, PsychInfo, CINAHL and Web Of Science), using a combination of medical subject headings (MeSH) and relevant text words. Observational studies including cross-sectional studies were included, but studies estimating the incidence of tinnitus (e.g. cohort studies) were outside the scope of this systematic review.ResultsThe databases identified 875 papers and a further 16 were identified through manual searching. After duplicates were removed, 515 remained. On the basis of the title, abstract and full-text screening, 400, 48 and 27 papers respectively were removed. This left 40 papers, reporting 39 different studies, for data extraction. Sixteen countries were represented, with the majority of the studies from the European region (38.5%). Publications since 2010 represented half of all included studies (48.7%). Overall prevalence figures for each study ranged from 5.1% to 42.7%. For the 12 studies that used the same definition of tinnitus, prevalence ranged from 11.9% to 30.3%. Twenty-six studies (66.7%) reported tinnitus prevalence by different age groups, and generally showed an increase in prevalence as age increases. Half the studies reported tinnitus prevalence by gender. The pattern generally showed higher tinnitus prevalence among males than females. There were 8 different types of definitions of tinnitus, the most common being "tinnitus lasting for more than five minutes at a time" (34.3%). Only seven studies gave any justification for the question that was used, or acknowledged the lack of standard questions for tinnitus. There is widespread inconsistency in defining and reporting tinnitus, leading to variability in prevalence estimates among studies. Nearly half of the included studies had a high risk of bias and this limits the generalisability of prevalence estimates. In addition, the available prevalence data is heterogeneous thereby preventing the ability to pool the data and perform meta-analyses. Sources of heterogeneity include different diagnostic criteria, different age groups, different study focus and differences in reporting and analysis of the results. Heterogeneity thus made comparison across studies impracticable.ConclusionDeriving global estimates of the prevalence of tinnitus involves combining results from studies which are consistent in their definition and measurement of tinnitus, survey methodology and in the reporting and analysis of the results. Ultimately comparison among studies is unachievable without such consistency. The strength of this systematic review is in providing a record of all the available, recent epidemiological data in each global region and in making recommendations for promoting standardisation.



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Auditory training improves auditory performance in cochlear implanted children

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Publication date: Available online 27 May 2016
Source:Hearing Research
Author(s): Stephane Roman, Françoise Rochette, Jean-Michel Triglia, Daniele Schön, Emmanuel Bigand
While the positive benefits of pediatric cochlear implantation on language perception skills are now proven, the heterogeneity of outcomes remains high. The understanding of this heterogeneity and possible strategies to minimize it is of utmost importance. Our scope here is to test the effects of an auditory training strategy, "sound in Hands", using playful tasks grounded on the theoretical and empirical findings of cognitive sciences. Indeed, several basic auditory operations, such as auditory scene analysis (ASA) are not trained in the usual therapeutic interventions in deaf children. However, as they constitute a fundamental basis in auditory cognition, their development should imply general benefit in auditory processing and in turn enhance speech perception.The purpose of the present study was to determine whether cochlear implanted children could improve auditory performances in trained tasks and whether they could develop a transfer of learning to a phonetic discrimination test.Material and methodsNineteen prelingually unilateral cochlear implanted children without additional handicap (4 to 10 year-olds) were recruited. The four main auditory cognitive processing (identification, discrimination, ASA and auditory memory) were stimulated and trained in the Experimental Group (EG) using Sound in Hands. The EG followed 20 training weekly sessions of 30 minutes and the untrained group was the control group (CG). Two measures were taken for both groups: before training (T1) and after training (T2).ResultsEG showed a significant improvement in the identification, discrimination and auditory memory tasks. The improvement in the ASA task did not reach significance. CG did not show any significant improvement in any of the tasks assessed. Most importantly, improvement was visible in the phonetic discrimination test for EG only. Moreover, younger children benefited more from the auditory training program to develop their phonetic abilities compared to older children, supporting the idea that rehabilitative care is most efficient when it takes place early on during childhood.These results are important to pinpoint the auditory deficits in CI children, to gather a better understanding of the links between basic auditory skills and speech perception which will in turn allow more efficient rehabilitative programs.



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Reliability of metatarsophalangeal and ankle joint torque measurements by an innovative device

Publication date: Available online 27 May 2016
Source:Gait & Posture
Author(s): Hok-Sum Man, Aaron Kam-Lun Leung, Jason Tak-Man Cheung, Thorsten Sterzing
The toe flexor muscles maintain body balance during standing and provide push-off force during walking, running, and jumping. Additionally, they are important contributing structures to maintain normal foot function. Thus, weakness of these muscles may cause poor balance, inefficient locomotion and foot deformities. The quantification of metatarsophalangeal joint (MPJ) stiffness is valuable as it is considered as a confounding factor in toe flexor muscles function.MPJ and ankle joint stiffness measurement is still largely depended on manual skills as current devices do not have good control on alignment, angular joint speed and displacement during measurement.Therefore, this study introduces an innovative dynamometer and protocol procedures for MPJ and ankle Joint torque measurement with precise and reliable foot alignment, angular joint speed and displacement control. Within-day and between-day test-retest experiments on MPJ and ankle joint torque measurement were conducted on ten and nine healthy male subjects respectively. The mean peak torques of MPJ and ankle joint of between-day and within-day measurement were 1.50±0.38Nm/deg and 1.19±0.34Nm/deg. The corresponding torques of the ankle joint were 8.24±2.20Nm/deg and 7.90±3.18Nm/deg respectively. Intraclass-correlation coefficients (ICC) of averaged peak torque of both joints of between-day and within-day test-retest experiments were ranging from 0.91 to 0.96, indicating the innovative device is systematic and reliable for the measurements and can be used for multiple scientific and clinical purposes.



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Παρασκευή 27 Μαΐου 2016

Review article: acute severe ulcerative colitis – evidence-based consensus statements

Summary

Background

Acute severe ulcerative colitis (ASUC) is a potentially life-threatening complication of ulcerative colitis.

Aim

To develop consensus statements based on a systematic review of the literature of the management of ASUC to improve patient outcome.

Methods

Following a literature review, the Delphi method was used to develop the consensus statements. A steering committee, based in Australia, generated the statements of interest. Three rounds of anonymous voting were carried out to achieve the final results. Acceptance of statements was pre-determined by ≥80% votes in 'complete agreement' or 'agreement with minor reservation'.

Results

Key recommendations include that patients with ASUC should be: hospitalised, undergo unprepared flexible sigmoidoscopy to assess severity and to exclude cytomegalovirus colitis, and be provided with venous thromboembolism prophylaxis and intravenous hydrocortisone 100 mg three or four times daily with close monitoring by a multidisciplinary team. Rescue therapy such as infliximab or ciclosporin should be started if insufficient response by day 3, and colectomy considered if no response to 7 days of rescue therapy or earlier if deterioration. With such an approach, it is expected that colectomy rate during admission will be below 30% and mortality less than 1% in specialist centres.

Conclusion

These evidenced-based consensus statements on acute severe ulcerative colitis, developed by a multidisciplinary group, provide up-to-date best practice recommendations that improve and harmonise management as well as provide auditable quality assessments.



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Patients with refractory reflux symptoms: What do they have and how should they be managed?

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Patients with refractory reflux symptoms: What do they have and how should they be managed?

Neurogastroenterol Motil. 2015 Sep;27(9):1195-201

Authors: Kahrilas PJ, Keefer L, Pandolfino JE

Abstract
With the widespread use of proton pump inhibitors (PPIs), the frontier of treating reflux disease has shifted from refractory esophagitis to PPI-refractory symptoms. However, symptoms are inherently less specific than mucosal disease and, as noted by Herregods et al. in their contribution appearing in this issue of Neurogastroenterology and Motility, patients with refractory gastroesophageal reflux disease (GERD) symptoms often do not have GERD. This review discusses potential etiologies for PPI-refractory symptoms. Three major concepts are explored: subendoscopic esophagitis, weakly acidic reflux events, and alternative explanations for persistent symptoms. With respect to subendoscopic esophagitis and unsuppressed reflux, ample evidence exists that these are present in PPI-refractory patients. The problem is that these findings are also often present in substantial numbers of individuals with a satisfactory response to PPI therapy. Hence, the emphasis shifts to determinants of symptom perception. The major conclusion of the review is that psychogenic factors such as hyperalgesia, allodynia, hypervigilance, and heightened anxiety are the most plausible explanations as the dominant determinants of PPI-refractory symptoms.

PMID: 26303047 [PubMed - indexed for MEDLINE]



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Laparoscopic repeat hepatectomy after right hepatopancreaticoduodenectomy

Abstract

Although laparoscopic hepatectomy is widely accepted for primary hepatectomy, the clinical value of laparoscopic hepatectomy for repeat hepatectomy is still challenging. We herein describe our experience with laparoscopic repeat hepatectomy after right hepatopancreaticoduodenectomy. A 72-year-old woman who had undergone right hepatopancreaticoduodenectomy for perihilar cholangiocarcinoma 31 months prior was diagnosed with liver metastasis in segment 3. We performed laparoscopic repeat hepatectomy. Because mild adhesions in the left side of the abdominal cavity were detected by laparoscopy, the planned procedure was accomplished. The operative time and intraoperative blood loss were 139 min and less than 1 mL, respectively. The patient was discharged at 6 days after surgery and was healthy with no evidence of recurrence at 21 months after laparoscopic repeat hepatectomy. Laparoscopic repeat hepatectomy is a suitable and safe procedure for minor hepatectomy, provided that careful technique is used after the working space is secured under pneumoperitoneum.



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Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients.

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Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients.

Neurogastroenterol Motil. 2015 Sep;27(9):1326-32

Authors: Gavini S, Finn RT, Lo WK, Goldberg HJ, Burakoff R, Feldman N, Chan WW

Abstract
BACKGROUND: Gastroesophageal reflux (GER) has been associated with idiopathic pulmonary fibrosis (IPF), although the mechanism remains unclear. Gastroesophageal reflux/microaspiration may lead to lung fibrosis, while increased pulmonary workload may also worsen GER. Comparing the GER profile of IPF patients to chronic obstructive pulmonary disease (COPD) patients with similar lung function may help delineate the role of GER in IPF pathogenesis.
METHODS: This was a retrospective cohort study of IPF and COPD patients undergoing pre-lung transplant multichannel intraluminal impedance and pH study (MII-pH) off acid suppression at a tertiary center in 2008-2014. Patients with prior fundoplication were excluded. Baseline demographics, pulmonary function test, and MII-pH results were recorded. Univariate analyses were performed using Fisher's exact (binary variables) and Student's t (continuous variables) tests. Logistic regression was performed to adjust for potential confounders.
KEY RESULTS: A total of 90 subjects (54 IPF, 36 COPD) met inclusion criteria. Compared to COPD, IPF patients had increased total reflux episodes (65.9 vs 46.1, p = 0.02), proximal reflux episodes (30.3 vs 20.3, p = 0.04), and prevalence of abnormal total reflux episodes (38.9% vs 16.7%, p = 0.02). On multivariate analyses, abnormal total reflux episodes (OR: 4.9, p = 0.05) and bolus reflux exposure time (OR: 4, p = 0.04) remained significantly associated with IPF.
CONCLUSIONS & INFERENCES: Abnormal reflux was significantly more prevalent among IPF patients after controlling for lung disease severity. Gastroesophageal reflux/microaspiration likely plays a role in fibrosis in IPF. A significant portion of IPF patients had increased non-acid reflux. Therapies aiming to prevent reflux of gastric contents may be more beneficial than antisecretory medications alone in these patients.

PMID: 26176338 [PubMed - indexed for MEDLINE]



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Serum Level of Trefoil Factor 2 can Predict the Extent of Gastric Spasmolytic Polypeptide-Expressing Metaplasia in the H. pylori-Infected Gastric Cancer Relatives

Abstract

Background & aims

Gastric cancer has familial clustering in incidence, and the familial relatives of gastric cancer sufferers are prone to have spasmolytic polypeptide-expressing metaplasia (SPEM), and intestinal metaplasia (IM) after H. pylori infection. This study tested whether serum pepsinogen I/II and trefoil factor family (TFF) proteins can predict SPEM or IM in the H. pylori-infected relatives of patients with gastric cancer.

Methods

We prospectively enrolled 119 H. pylori-infected relatives of gastric cancer patients of noncardiac gastric cancer patients, who then received panendoscopy to obtain gastric biopsy to define the presence of corpus gastritis index (CGI), SPEM, and IM. The advanced SPEM in histology was defined by TFF2 immunohistochemistry. Each patient also had checkups of serum TFF2, TFF3, and pepsinogen I/II by enzyme-linked immunosorbent assay (ELISA).

Results

The 119 H. pylori-infected relatives included 61 with SPEM, and 34 with IM. The presence of either IM or SPEM was not related to the serum TFF2, TFF3, and pepsinogen I/II levels (p > .05). Serum TFF2 levels were higher in relatives with CGI who also had advanced SPEM (p = .032). For relatives without CGI, the elevated serum TFF2 levels correlated with higher H. pylori density and more severe gastritis in antrum (p = .001).

Conclusion

The serum TFF2 level cannot predict SPEM or IM in H. pylori-infected relatives of patients with gastric cancer. For H. pylori-infected relatives with CGI, serum TFF2 levels may predict the advanced severity of SPEM. Elevated serum TFF2 levels may indicate severe H. pylori-related inflammation, at risk of development or progression of SPEM in relatives without CGI.



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The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters.

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The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters.

Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3375-83

Authors: Sahin M, Vardar R, Ersin S, Kirazli T, Ogut MF, Akyildiz NS, Bor S

Abstract
The aim of this study was to evaluate the effect of laparoscopic antireflux surgery (LARS) on the laryngeal symptoms, physical findings and voice parameters of gastroesophageal reflux disease (GERD) patients with or without laryngopharyngeal reflux (LPR). Forty-one GERD patients predominantly with LPR symptoms (Group I) and twenty-six GERD patients without LPR symptoms (Group II) who had LARS were prospectively analysed before and 2 years after the surgery. Upper gastrointestinal endoscopy, 24-h ambulatory pH or MII-pH monitoring was performed in all cases. A reflux study group including specialists from five departments in a university hospital decided surgical indications. Patients were asked to fill out a validated LPR and voice quality questionnaire (Reflux Symptom Index and Voice Handicap Index-10). Laryngeal findings were evaluated and scored using a laryngoscopic grading scale [Reflux Finding Score (RFS)], by four blinded ENT specialists. GRBAS scale was done by a blinded otolaryngologist. Voice parameters were measured objectively via the Multi Dimensional Voice Programme (MDVP). The mean age was 45.8 ± 8.5 for Group I (24 men) and 48.9 ± 12.3 for Group II (16 men). The mean follow-up after LARS was 24.5 ± 1.3 months for Group I and 25.2 ± 1.1 months for Group II. The preoperative mean score of RSI was 22.8 ± 7.4 vs. 11.2 ± 6.6; RFS was 10.6 ± 2.3 vs. 5.7 ± 2.5 and VHI was 18.07 ± 4.4 vs. 10.86 ± 3.3 for Group I and II, respectively. The postoperative mean score of RSI was 12.9 ± 6.4 vs. 8.4 ± 4.5; RFS was 6.9 ± 2.0 vs. 4.5 ± 2.3 and VHI was 9.59 ± 4.4 vs. 7.95 ± 3.5 for Group I and II, respectively. Group I had significantly lower RSI and RFS scores following LARS compared to the preoperative scores. LARS successfully improved RFS, RSI and VHI in carefully selected patients with GERD, especially the signs and symptoms related to the larynx and voice. Although the indications for LARS are limited in patients with LPR symptoms, these results favor the decision-making period of LARS.

PMID: 26116011 [PubMed - indexed for MEDLINE]



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