Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: A critical review

Publication date: May 2016
Source:Oral Oncology, Volume 56
Author(s): Janine Mayra da Silva, Danilo Figueiredo Soave, Tálita Pollyanna Moreira dos Santos, Aline Carvalho Batista, Remo Castro Russo, Mauro Martins Teixeira, Tarcília Aparecida da Silva
Chemokines are small chemotactic proteins that coordinate circulation of immune/inflammatory cells throughout body compartments. Because of this property chemokines and their cell surface receptors are implicated in several physiological and pathological conditions, including cancer. These molecules are expressed by neoplastic or stromal cells and have effects at tumor primary site (e.g. stimulating angiogenesis and tumor cells motility) and lymph nodes (creating a gradient to direct migration of neoplastic cells). In this article we review the current knowledge about the function(s) of chemokines and receptors in squamous cell carcinoma from the oral cavity and head and neck region. Accumulating evidence suggests some chemokine(s) and receptor(s) as potential targets in adjuvant therapies for these malignancies.



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