Osteoradionecrosis in patients with salivary gland malignancies

Publication date: June 2016
Source:Oral Oncology, Volume 57
Author(s): J. Rhet Tucker, Li Xu, Erich M. Sturgis, Abdallah S.R. Mohamed, Theresa M. Hofstede, Mark S. Chambers, Stephen Y. Lai, Clifton David Fuller, Beth Beadle, G. Brandon Gunn, Katherine A. Hutcheson
PurposeThe present study was undertaken to evaluate osteoradionecrosis (ORN) in patients with salivary gland malignancies (SGM) after treatment with radiation therapy.Materials and methodsThe medical records of 172 patients treated with radiation therapy for SGM during a 12-year period (August 2001 to November 2013) were reviewed. Incidence, time to event, staging and management of ORN were analyzed.ResultsOf the 172 patients, 7 patients (4%) developed ORN (median latency: 19months, range: 4–72months). Of those 7 patients, 4 required major surgery, 1 required hyperbaric oxygen therapy (HBO), one required minor debridement, and one required conservative management. Total prescribed radiation dose varied from 50Gy (1 case) to 70Gy (1 case) among those patients who developed ORN, and radiotherapy was delivered postoperatively after osseous resection in 4 of 7 cases. Three of the 7 cases of ORN occurred after traumatic injury to the bone. Of the 7 patients who developed ORN, 3 had SGM of the major glands, 3 had other sites of the oral cavity, and 1 had a sinonasal location.ConclusionWhile the rate of ORN after radiotherapy for SGM was somewhat lower (4%) than previously published data on patients with squamous cell carcinomas of the head and neck treated with radiation therapy (8–14%), ORN necessitating major surgery remains a clinically significant, possible late effect of radiotherapy in SGM survivors. Location of SGM is very important, with cases that developed ORN disproportionally having primary disease arising in the oral cavity.



from #ORL via xlomafota13 on Inoreader http://ift.tt/1M3zoJZ
via IFTTT