A new diagnosis of upper airway human papillomavirus (HPV)–related disease, benign or malignant, invariably leads to some challenging discussions with patients and families. These clinical encounters often involve delicate, pointed, and sometimes uncomfortable follow-up queries from patients that are fairly unique in the world of otolaryngologic care: "How did I get this?" "Do I need to tell my wife/husband?" "Am I infectious?" "Do we need to use barrier protection?" "Does my wife/husband need to do anything to prevent this?" "Am I putting him/her at risk?" "Should he/she be vaccinated?" "What about our children?"
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