Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection.

Related Articles

Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection.

Nat Commun. 2015;6:6592

Authors: Yang B, Feng L, Wang F, Wang L

Abstract
Enterohemorrhagic Escherichia coli (EHEC) is an important foodborne pathogen that infects humans by colonizing the large intestine. Here we identify a virulence-regulating pathway in which the biotin protein ligase BirA signals to the global regulator Fur, which in turn activates LEE (locus of enterocyte effacement) genes to promote EHEC adherence in the low-biotin large intestine. LEE genes are repressed in the high-biotin small intestine, thus preventing adherence and ensuring selective colonization of the large intestine. The presence of this pathway in all nine EHEC serotypes tested indicates that it is an important evolutionary strategy for EHEC. The pathway is incomplete in closely related small-intestinal enteropathogenic E. coli due to the lack of the Fur response to BirA. Mice fed with a biotin-rich diet show significantly reduced EHEC adherence, indicating that biotin might be useful to prevent EHEC infection in humans.

PMID: 25791315 [PubMed - indexed for MEDLINE]

from #ΓεύσηΌσφρηση via a.lsfakia on Inoreader http://ift.tt/1ocT8iD
via IFTTT