Elimination and elemental diet therapy in eosinophilic oesophagitis.

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Elimination and elemental diet therapy in eosinophilic oesophagitis.

Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):793-803

Authors: Warners MJ, Vlieg-Boerstra BJ, Bredenoord AJ

Abstract
Eosinophilic oesophagitis (EoE) is a chronic immune-mediated disorder of the oesophagus. The incidence of EoE has been raised substantially and EoE has recently become the most prevalent cause of dysphagia among the adolescents. Food and aeroallergens are believed to play a major role in the pathogenesis. Current treatment includes topical steroids and dietary therapy. Dietary therapy with elimination of causative allergens could provide a durable long-term solution. Dietary therapy in EoE consists of in elemental and empiric elimination diets. Elemental diet with amino acid-based formula is most effective in achieving disease remission but poor taste makes adherence challenging. Empiric elimination diet based on avoidance of most common food allergens offers moderate response rates, the usefulness of allergy test-directed elimination diets is questioned by low response rates. In conclusion, dietary treatments for EoE seem promising, but further refinement is required before it can become standard care.

PMID: 26552778 [PubMed - indexed for MEDLINE]

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