Association of genetic variants with tumor HPV16 status and survival in squamous cell carcinoma of the oropharynx

Squamous cell carcinoma of the oropharynx (SCCOP) is a subtype of squamous cell carcinoma of the head and neck (SCCHN) [1]. In the U.S., approximately 13,510 new cases of SCCOP are diagnosed, and 2330 deaths result from these cancers, annually [2]. Although tobacco smoking and alcohol consumption remain significant risk factors for SCCOP, human papillomavirus (HPV) accounts for a growing proportion of cases, particularly in young adults [1,3]. There are more than 100 different HPV types; about 20 of these have oncogenic potential (i.e., the high-risk types) [4].

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