Meta-analysis of 701 published cases of sinonasal neuroendocrine carcinoma: The importance of differentiation grade in determining treatment strategy

Sinonasal tumors with neuroendocrine differentiation are a rare group of neoplasms that account for only 5% of all sinonasal malignancies [1]. A broad distinction is made between tumors of neuroectodermal origin - esthesioneuroblastoma - and those of epithelial origin - sinonasal neuroendocrine carcinoma (SNC). The latter can be subdivided based on differentiation grade into well, moderately and poorly differentiated SNC. Poorly differentiated SNC are further subdivided into a small and large cell variants.

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