Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.

Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.

Drug Discov Today. 2016 Oct 26;:

Authors: Kuruva CS, Reddy PH

Abstract
Multiple cellular changes have been identified as being involved in Alzheimer's disease (AD) pathogenesis, including mitochondrial damage, synaptic loss, amyloid beta (Aβ) production and/or accumulation, inflammatory responses, and phosphorylated tau formation and/or accumulation. Studies have established that Aβ-induced synaptic dysfunction is dependent on abnormal amyloid precursor protein (APP) processing caused by β- and γ-secretases, resulting in the generation of Aβ. The Aβ formed as a result of abnormal APP processing induces phosphorylated tau and activates glycogen synthase kinase-3β (GSK3β) and cyclin-dependent kinase-5 (CDK5). Here, we review the latest research on the development of Aβ modulators for neuroprotection in AD. We also review the use of molecular inhibitors as therapeutic targets in AD.

PMID: 27794478 [PubMed - as supplied by publisher]

from Speech via a.lsfakia on Inoreader http://ift.tt/2fw2W7B
via IFTTT