Sleep changes in Alzheimer's disease spectrum disorders measured by home-based polysomnography

Introduction: There have been several human studies regarding sleep parameters and their potential relationship with Alzheimer's disease (AD) pathogenesis. In this pilot study we investigated sleep architecture in subjective memory impairment (SMI), mild cognitive impairment (MCI), and AD patients who completed amyloid PET scans prior to assessment of their sleep architecture using WatchPAT® which enables measurements of sleep parameters at home. We hypothesized that patients with AD spectrum disorders or subjects with amyloid pathology in the brain may have more sleep problems.

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