Salivary proteomics in lichen planus: A relationship with pathogenesis?

Abstract

Objectives

Oral lichen planus is a chronic, T-cell-mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocytes pathways induce apoptosis with an increase of Th1 and Th17 subtypes cells, triggered by the release of cytokines; This study analysed saliva proteomics to identify protein markers that might be involved in the pathogenesis and development of the disease.

Material And Methods

Proteins differentially expressed by oral lichen planus and healthy controls were screened using mass spectrometry; the proteins found in oral lichen planus were subjected to bioinformatics analysis, including gene ontology and string networks analysis. The multiplex analysis validation allowed the correlation between the proteins identified and the involved cytokines in Th17 response.

Results

108 proteins were identified in oral lichen planus, of which 17 proteins showed a high interaction between them and indicated an association with the disease. Expression of these proteins was correlated with the triggering of cytokines, more specifically the Th17 cells.

Conclusions

Proteins, such as S100A8, S100A9, Haptoglobin can trigger cytokines and might be associated with a pathological function and antioxidant activities in oral lichen planus.

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