Overlap Parasomnia Disorder in a case of Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease (CJD), the most common human prion disease, is a rare form of adult fatal dementia caused by widespread brain accumulation of abnormal isoform (PrPSc) of the host encoded cellular prion protein (PrPC)1,2. CJD is characterized by rapidly progressive dementia, associated with numerous neurological symptoms and signs, including referred insomnia and hypersomnia3. So far, few video-polysomnographic data are available in CJD, documenting a reduction of SWS and REM sleep, and loss of sleep-wake cyclic organization4,5.

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