Default mode network disturbances in restless legs syndrome/Willis-Ekbom disease

• This study investigated the default mode network (DMN) in restless legs syndrome/Willis–Ekbom disease (RLS/WED) subjects.• The results showed DMN disturbances in RLS/WED subjects.• This may be related to compensatory changes to maintain resting.• These findings give more insight in to understanding RLS/WED.

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