[The change of vaginal lactobacillus in patients with high-risk human papillomavirus infection].

[The change of vaginal lactobacillus in patients with high-risk human papillomavirus infection].

Zhonghua Yi Xue Za Zhi. 2016 Jul 5;96(25):2006-8

Authors: Zhou D, Cui Y, Wu FL, Deng WH

Abstract
OBJECTIVE: To study the distribution characteristics of lactobacillus in the vaginal mucosa of patients with HPV infection.
METHODS: The planting density of lactobacillus in vaginal secretions of 95 cases with HPV16/18 infection and 90 cases of normal women of childbearing age were observed by oil microscope. And the strains of vaginal lactobacilli in two groups were analyzed using species-specific polymerase chain reaction (Species-specific PCR) and the distribution of vaginal lactobacilli in patients with HPV16/18 infection were investigated.
RESULTS: In HPV16/18 infective groups, the planting density of lactobacillus in the vaginal mucosa was 104 (68-186)/HP. It was significantly lower than that of the normal group (234 (161-326)/HP, P<0.05). Compared with the normal group, the positive rates of lactobacillus iners, lactobacillus crispatus, and lactobacillus gasseri were significantly lower in HPV16/18 infection group (P<0.05).
CONCLUSION: The HPV16/18 infection is associated with the decreased number of lactobacillus and the imbalance of vaginal flora; Lactobacillus iners, lactobacillus crispatus, and lactobacillus gasseri may play a key role in maintaining the vaginal micro ecological environment.

PMID: 27470959 [PubMed - in process]

from #ORL via xlomafota13 on Inoreader http://ift.tt/2aRFxsl
via IFTTT