[Hyperthyroid and acute tonsillitis in a 23-year-old woman].

[Hyperthyroid and acute tonsillitis in a 23-year-old woman].

Internist (Berl). 2016 Apr 13;

Authors: Beyer G, Küster I, Budde C, Wilhelm E, Hoene A, Evert K, Stracke S, Friesecke S, Mayerle J, Steveling A

Abstract
A 23-year-old woman with preexisting Graves' disease who received thiamazole treatment presented with fever, dysphagia, hyperthyroidism and leukopenia. With suspicion of thyreotoxicosis accompanied by drug-induced agranulocytosis she was successfully managed by plasmapheresis, G‑CSF administration and inhibition of periphereal conversion of thyroid hormones. In due course she underwent thyroidectomy. Thiamazole is frequently associated with drug-induced agranulocytosis. Long-term therapy with thiamazole requires critical evaluation and alternatives should be considered early. Plasmapheresis is an adequate treatment option to achieve normal thyroid hormonal status.

PMID: 27075316 [PubMed - as supplied by publisher]

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