Dexmedetomidine and Mannitol for Awake Craniotomy in a Pregnant Patient.

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Dexmedetomidine and Mannitol for Awake Craniotomy in a Pregnant Patient.

Anesth Analg. 2015 May;120(5):1099-103

Authors: Handlogten KS, Sharpe EE, Brost BC, Parney IF, Pasternak JJ

Abstract
We describe the use of dexmedetomidine for an awake neurosurgical procedure in a pregnant patient and quantify the effect of mannitol on intrauterine volume. A 27-year-old woman underwent a craniotomy, with intraprocedural motor and speech mapping, at 20 weeks of gestation. Sedation was maintained with dexmedetomidine. Mannitol at 0.25 g/kg IV was administered to control brain volume during surgery. Internal uterine volume was estimated at 1092 cm before surgery and decreased to 770 and 953 cm at 9 and 48 hours, respectively, after baseline assessment. No adverse maternal or fetal effects were noted during the intraoperative period or up to 48 hours postoperatively.

PMID: 25899274 [PubMed - indexed for MEDLINE]

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