Do we need 5-FU in addition to cisplatin for chemoradiation of locally advanced head-and-neck cancer?

The survival of patients with squamous cell carcinoma of the head-and-neck (SCCHN) has improved during the last 15years [1]. However, many of these patients present with locally advanced or even metastatic disease. The outcome of therapy particular of these patients groups can be further improved. Randomized trials demonstrated that definitive chemoradiation resulted in significantly better treatment outcomes than radiotherapy alone for locally advanced SCCHN [2–4]. In a subsequent large meta-analysis of 16,485 patients from 2009, simultaneous chemoradiation was superior to chemotherapy followed by irradiation in terms of significantly better loco-regional control (LRC) and overall survival (OS) [5].

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