Successful lung transplantation for chronic Mycobacterium abscessus infection in advanced cystic fibrosis, a case series

Abstract

Pulmonary Mycobacterium abscessus infection in cystic fibrosis (CF) patients is difficult to treat and considered a contra‐indication for lung transplantation in most centers. We present four CF patients with chronic pulmonary M. abscessus infection, in whom lung transplantation was performed. Through intensive treatment before transplantation, we achieved control of the infection in all but one patient. After a mean of 16 months of follow up, three patients are doing well, without evidence of local or disseminated recurrence. One patient died early post‐transplant due to an unrelated cause. These findings support the possibility of lung transplantation with favorable outcome in CF patients with M. abscessus infection.

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