Association of a TNFSF13B (BAFF) regulatory region single nucleotide polymorphism with response to rituximab in ANCA-associated vasculitis

Publication date: Available online 22 October 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Federico Alberici, Rona M. Smith, Mariana Fonseca, Lisa C. Willcocks, Rachel B. Jones, Julia U. Holle, Stefan Wieczorek, Thomas Neumann, Davide Martorana, Gina Gregorini, Renato A. Sinico, Annette Bruchfeld, Iva Gunnarsson, Sophie Ohlsson, Bo Baslund, Vladimir Tesar, Zdenka Hruskova, Maria C. Cid, Augusto Vaglio, Paul A. Lyons, Kenneth G.C. Smith, David R.W. Jayne

Teaser

In ANCA-associated vasculitis (AAVs) response to rituximab is highly variable and predictors of response are needed. Our study identifies a single nucleotide polymorphism of the regulatory region of TNFSF13B (BAFF) associated with response to rituximab in AAV.


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