Steroid therapy ameliorated cataplexy in three children with recent-onset of narcolepsy

Autoimmune mechanism is implicated in the pathology of narcolepsy [1]. We reported favorable effects of steroid therapy on three recent onset children who suffered from narcolepsy with cataplexy. Three children showed excessive daytime sleepiness and cataplexy, and were diagnosed as narcolepsy by undetectable hypocretin 1 levels in the cerebrospinal fluids (CSF) and the presence of sleep onset rapid eye movement (REM) period. They aged from 5 to 13 years, and patient 1 was a girl, while patients 2 and 3 were boys.

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