Thiol/Disulfide Homeostasis in Bell's Palsy as a Novel Pathogenetic Marker

Abstract

Objective

The aim of this study was to investigate the relationship between Bell's palsy and a novel oxidative stress parameter, thiol/disulphide homeostasis

Design and Setting

Totally 77 patients with Bell's palsy and 38 healthy controls were included in this study. The blood levels of total and native thiol and disulphide activity were assessed, and their levels were compared in the patients and controls.

Results

There were statistically significant differences between the patients and controls regarding thiol/disulfide parameters. The mean native thiol and total thiol were significantly lower and disulfide levels were higher in the Bell's palsy than controls. On binary logistic regression analysis, the created model showed 45.3 % variation. The cut-off value was 18.95 for disulfides.

Conclusion

Native and total thiol levels were low in the Bell's palsy. This metabolic disturbance may have a role in the pathogenesis of Bell's palsy.

This article is protected by copyright. All rights reserved.

from #ORL via xlomafota13 on Inoreader http://ift.tt/29kYUbG
via IFTTT