Salivary Gland. Photon beam and particle radiotherapy: Present and future

Salivary gland cancers (SGCs) are uncommon diseases accounting for only 2–6.5% of all head and neck cancers, and are characterized by considerable variability in their biology and natural history [1]. Mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and adenocarcinoma are the most frequent diagnoses, representing >75% of all SGCs, although their frequency varies according to the site of origin (major vs minor salivary glands) [2]. Prognosis among SGCs differs according to histology and grading: non-ACC and high-grade tumors are associated with a poorer prognosis compared with low-grade tumors [3–5].

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