Relation between chronic rhinosinusitis and gastroesophageal reflux in adults: systematic review

Publication date: Available online 14 July 2016
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Guilherme Constante Preis Sella, Edwin Tamashiro, Wilma Terezinha Anselmo-Lima, Fabiana Cardoso Pereira Valera
IntroductionThe relationship between gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) is still a controversial issue in literature.ObjectiveA systematic review of the association between these two diseases in adult patients.MethodsSystematic review in PubMed and Cochrane Database with articles published between 1951 and 2015. We included all articles that specifically studied the relationship between CSR and GERD.ResultsOf the 436 articles found, only 12 met the inclusion criteria. Eight cross-sectional articles suggest a relation between CRS and GERD, especially on CRS that is refractory to clinical or surgical treatment. However, the groups are small and methodologies are different. Four other longitudinal studies have assessed the effect of treatment with proton pump inhibitors (PPIs) on the improvement of symptoms of CRS, but the results were conflicting.ConclusionsThere seems to be relative prevalence of reflux with intractable CRS. There is still a lack of controlled studies with a significant number of patients to confirm this hypothesis. Few studies specifically assess the impact of treatment of reflux on symptom improvement in patients with CRS.



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