Quercetin, not caffeine, is a major neuroprotective component in coffee

Publication date: Available online 5 July 2016
Source:Neurobiology of Aging
Author(s): Moonhee Lee, Edith G. McGeer, Patrick L. McGeer
Epidemiological studies indicate that coffee consumption reduces the risk of Parkinson's disease (PD) and Alzheimer's disease (AD). To determine the factors involved, we examined the protective effects of coffee components. The test involved prevention of neurotoxicity to SH-SY5Y cells that was induced by LPS/IFNγ or IFNγ released from activated microglia and astrocytes. We found that quercetin, flavones, CGA and caffeine protected SH-SY5Y cells from these toxins. They also reduced the release of TNFα and IL-6 from the activated microglia and astrocytes, and attenuated the activation of proteins from P38 MAPK and NFκB. Following exposure to toxin containing glial stimulated conditioned medium, we also found that quercetin reduced oxidative/nitrative damage to DNA, as well as to the lipids and proteins of SH-SY5Y cells. There was a resultant increase in [GSH]i in SH-SY5Y cells. The data indicate that quercetin is the major neuroprotective component in coffee against PD and AD.



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