A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder

• Clonazepam reduced vigorous verbal and motor behaviors, with two thirds of patients free from sleep-related injuries.• Residual rapid eye movement sleep behavior disorder (RBD) symptoms, however, were common, despite treatment.• Clonazepam changed dream affect and content while reducing motor activities.• Less optimal treatment response was associated with younger age and comorbid obstructive sleep apnea.• RBDQ-3M, a self-administered modified RBDQ scale, could be a sensitive and valid tool to monitor the treatment progress

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