Risk factors for Barrett’s esophagus

ABSTRACT

Barrett's esophagus (BE) is a well-recognized precursor for esophageal adenocarcinoma (EAC) and is defined as ≥1 cm segment of salmon colored mucosa extending above the gastroesophageal junction into the tubular esophagus with biopsy confirmation of metaplastic replacement of the normal squamous epithelium by intestinal-type columnar epithelium. The incidence of both BE and EAC has been increasing over the past few decades. As a result, preventing the development of BE by identifying and understanding its modifiable and non-modifiable risk factors may help reduce the incidence of EAC. Over the recent past, a tremendous amount of progress has been made towards improving our knowledge of risk factors and pathogenesis of BE. This article reviews the evidence for the various risk factors for development of BE. This article is protected by copyright. All rights reserved.

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