Fatty acid synthase (FASN) and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.

Fatty acid synthase (FASN) and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma.

J Oral Pathol Med. 2018 Dec 29;:

Authors: Díaz KP, Gondak R, Liporoni LM, de Almeida OP, León JE, Mariano FV, Altemani A, Vargas PA

Abstract
BACKGROUND: Fatty Acid Synthase (FASN) is the key molecule for catalyzing fatty acid synthesis and have been associated with several malignant tumors.
METHODS: We analyzed the expression of FASN and Ki-67, by immunohistochemistry on 29 carcinomas ex-pleomorphic adenoma (CXPAs) and 25 pleomorphic adenomas (PAs).
RESULTS: Ki-67 proliferation index and FASN expression were significantly higher in patients with CXPA than patients with PA (P < 0.001). We found intense immunoreactivity for FASN in the malignant component of CXPAs and these malignant areas also had intense nuclear immunoreactivity for Ki-67.
CONCLUSIONS: The present results suggest that overexpression of FASN in CXPAs might be associated with malignant transformation of ductal epithelial cells and/or myoepithelial cells from PA. FASN associated with Ki-67 may be useful diagnostic markers for CXPA. This article is protected by copyright. All rights reserved.

PMID: 30597641 [PubMed - as supplied by publisher]

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