Prognostic impact of adjuvant chemotherapy in high-risk nasopharyngeal carcinoma patients

Nasopharyngeal carcinoma (NPC) is distinct from other cancers of the head and neck by its epidemiology, histopathology, clinical characteristics, methods of treatment, and patterns of failure. Because of the inherent anatomic constraints and a high degree of radiosensitivity, radiotherapy (RT) has been the primary treatment for NPC patients without distant metastasis. NPC is also a chemosensitive tumor. More and more evidences have supported that RT combined with neoadjuvant chemotherapy (NeoCT) and/or concurrent chemotherapy (ConCT) is the best initial treatment modality for patients with locoregionally advanced diseases [1–12].

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