Abstract
Background
Dental implants often have surface modifications that alter surface topography and chemistry to improve osseointegration and thereby increase treatment predictability. Surface contact‐induced blood coagulation is associated with the onset of osseointegration.
Purpose
To quantitatively evaluate the thrombogenicity of two commercially available dental implants that have similar surface roughness but different surface chemistry.
Material and Methods
Two commercially available dental implants with anodized or sandblasted acid‐etched surfaces were evaluated for thrombogenic properties. Thrombogenicity was assessed by incubating implants for 1 hour in fresh, partially heparinized blood followed by hemocyte quantification, microscopic evaluation, and quantification of thrombogenic biomarkers.
Results
Fibrin coverage was significantly higher on the anodized surface compared with the sandblasted acid‐etched surface (P < 0.0001). Platelet and white blood cell attachment followed a similar pattern. The increased thrombogenicity was confirmed based on a significant increase in the levels of the coagulation cascade biomarkers, thrombin antithrombin complex, and β‐thromboglobulin (all P < 0.05).
Conclusion
Dental implants with comparable roughness but differing surface chemistry had differing extents of blood contact activation. These data suggest that surface chemistry from anodization augments implant thrombogenicity compared with that from sandblasting and acid‐etching, which could have implications for osseointegration.
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